The Nigrovic lab at the Brigham and Women’s Hospital and Harvard Medical School is seeking a postdoctoral fellow to spearhead NIH-funded studies exploring the immune role of megakaryocytes, including via emperipolesis, a new form of cell-in-cell interaction between megakaryocytes and neutrophils.
This work will build on our observation that megakaryocytes contribute to systemic inflammatory disease, even independent of their platelets (J Clin Invest. 2017 May 1;127(5):1714-1724; reviewed in J Leuk Biol 2019 Jun;105(6):1111-1121). We seek to understand how how megakaryocytes function as immune cells through their surface receptors, soluble mediators, and microparticles. We seek to deepen our understanding of emperipolesis, whereby neutrophils penetrate into the megakaryocyte cytoplasm to pass surface membrane to platelets before leaving intact (eLife 2019;8:e440312019). We will explore the cell biology of emperipolesis as well as its implications for the function of megakaryocytes, neutrophils and platelets.
Applicants should have a PhD (or MD with substantial laboratory experience) related to cellular and immune biology. Specific megakaryocyte, platelet, and/or neutrophil experience is helpful but not required.
The Nigrovic lab (www.nigroviclab.org) is a 13-member basic and translational research group based in the Brigham and Women’s Hospital, Boston, and focused on immune-mediated disease. Funding is provided by 3 NIH R01 grants and other awards. Human samples are available through the PI’s NIAMS-funded Joint Biology Consortium (www.jbcwebportal.org). Successful applicants will have a track record of productivity that confirms their ability to work independently at a high level in a friendly, collegial, and supportive but demanding environment. Potential for partial self-funding is welcome but not essential.
Inquiries and applications (including CV, name/email address of 2-3 referees, and reprints of 2 most significant publications) should be directed to:
Peter A. Nigrovic, MD
Associate Professor of Medicine, Harvard Medical School