Temple University

Postdoctoral Position in Gene Expression Regulation and Stem Cells

Conchi Estaras

Philadelphia, PA, United States


Topic:Transcription and Epigenetic Regulation in human Embryonic Stem cells and Cardiac Development

Center for Translational Medicine

Lewis Katz School of Medicine

Temple University, Philadelphia, Pennsylvania (US)

A post-doctoral position is available at the laboratory of Stem Cells and Cardiac Development headed by Conchi Estaras, PhD(https://sites.temple.edu/estaraslab).

Our new research laboratory forms part of the Center for Translational Medicine at the Lewis Katz School of Medicinein Temple University (Philadelphia). We are part of a diverse and highly collaborative scientific community encouraging interdisciplinary collaborations between the basic and translational research programs.

In our lab, we focus on identifying the molecular mechanisms that control stem cell differentiation toward specific cardiac lineages. We aim to decipher signaling pathways, transcriptional and epigenetic mechanisms that regulate specific cardiac cell fates.  We want to use this knowledge to identify mechanisms and factors important for cardiac cell development and to provide new tools to design stem cell-based strategies for cardiac repair.

Our main models of study are human embryonic stem cells (hESCs) and induced Pluripotent Stem Cells (iPSCs). We use directed differentiation strategies together with cardiac organoids to mimic early cardiac cell development. We apply a wide-range of techniques to obtain a comprehensive panel of the transcriptome and the epigenome of the cells during cardiac cell fate acquisition; from conventional western-blot and qPCR to next-generation sequencing (RNA-seq, GRO-seq, ChIP-seq, ATAC-seq, and single-cell sequencing).

If you want to know more about our projects, contact us! We are seeking for enthusiastic candidates with a MD and/or PhD to join our new lab. We also encourage candidates with experience in one or more of the following areas to apply: stem cells, cardiac development, transcription, epigenetics, bioengineering, genomics and/or bioinformatics.

The position offers salary consistent with NIH guidelines and a competitive benefits package. This is a fully funded position for at least 2 years (with possibility to extend).

To apply, please send your CV, cover letter with your motivation for this position, and names of 2 academic references to conchi.estaras@temple.edu


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Postdoctoral Position in Gene Expression Regulation and Stem Cells