Washington University School of Medicine (WUSM), WUSTL

Postdoctoral Position in Alzheimer Disease Genetics and Genomics

NeuroGenomics and Informatics

St. Louis, MO, United States

The NeuroGenetics and Informatics (NGI) group (https://neurogenomics.wustl.edu/) at Washington University School of Medicine is recruiting multiple Postdoctoral Research Scientists. The NGI generates and analyzes Whole-Genome Sequencing data and high-throughput multi-dimensional omic data to study neurodegeneration and diseases of the central nervous system with emphasis on Alzheimer’s disease, Parkinson’s disease, and other dementias. The ultimate goal of the NGI is to understand the biology of these diseases, to define novel biomarkers, and to identify novel therapeutical targets. Washington University School of Medicine is renowned for its research cohorts of neurodegenerative disorders, which include clinical, neuroimaging, and fluid biomarker phenotypes.

We have pioneered the use of Whole Exome and Whole Genome sequencing data in familial (Cruchaga et al., Nature 2013., Fernandez et al., Eur J HumGenet 2016, Fernandez et al., PLoS Genetics 2017, Fernandez et al., Front Neuroscience 2018) and sporadic (Jin et al., Alzheimer Res Ther 2012, Benitez et al., PLoS Genetics, 2013, Benitez et al., N Engl J Med 2013 Jin SC Human Mol Genet 2014) Alzheimer disease to identify novel variants and genes associated with disease risk.

We have recently received several NIH R01 awards to generated and analyze large WGS dataset for both familial Alzheimer Disease and sporadic early-onset cases. We are seeking highly motivated researchers with strong analytical skills, especially in genetics and WGS/WES analyses to lead the analyses for these projects. The new postdoc(s) will join a large team, currently twenty members, which is led by three faculty members, four postdocs, several PhD students and three senior scientists.

For further details please see our website: https://neurogenomics.wustl.edu/.


Required Qualifications

  • The successful applicant will hold, or shortly expects to obtain, a PhD qualification in Genetics, Bioinformatics, Computer Science, Data Science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets.
  • Hands-on experience with large-scale human genomic (PLINK, SKAT, BWA, GATK) or other omics (preferably related to neurodegeneration) studies is expected.
  • Solid skills in at least one programming language (R, python or perl) and experience working in Linux and/or high-performance cluster environments.
  • A strong ability to perform analytical reasoning to extract biological insights from data-driven approaches will be critical.
  • Familiarity to interrogate publicly available resources will be highly beneficial.


Department Name/Job Location

This position is the NeuroGenomics and Informatics group (Department of Psychiatry) at Washington University.


Benefits

This position is eligible for full-time benefits. Please click the following link to view a summary of benefits: https://hr.wustl.edu/benefits/.


Applicant Special Instructions

Interested candidates should send their cover letter and CV to Drs. Cruchaga (cruchagac_at_wustl.edu )


EOE Statement

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

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Position

Postdoctoral Position in Alzheimer Disease Genetics and Genomics