The Cancer and Developmental Biology Laboratory (CDBL) within the Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) currently has openings for highly motivated postdoctoral fellows to train within the program areas of several of its Senior Investigators. CDBL’s research focuses on the analysis of embryonic development, particularly the mechanisms of growth control, the regulation of differentiation and morphogenesis through several signaling pathways that are also involved in cancer progression. The CDBL is comprised of six principal investigators who are exceptionally interactive and collaborative, prioritizing the success of our trainees through weekly post-doc seminars, in-depth mentoring sessions, yearly combined retreats, lab group participation in regional scientific meetings, and more. Fellowships offered are as follows:
Developmental Signal Transduction Section – Ira O. Daar, Ph.D. Email: firstname.lastname@example.org
A postdoctoral position is available in 2020 to study the role of Eph receptors, ephrin ligands, and Wnt signaling pathways in cell movement and morphogenesis (e.g. Lee et al., J. Cell Biol. 218:2659-2676, 2019; Yoon et al., Nature Comm. 9:3491, 2018; Cho et al., Oncogene 37:861-872, 2018). A combination of molecular, cell biological, and biochemical techniques are applied in the amphibian developmental and mammalian culture systems.
Genetics of Vertebrate Development Section – Mark B. Lewandoski, Ph.D. Email: email@example.com
A postdoctoral position is available immediately to study the genetics of development in the mammalian embryo. The focus of the lab is the role of cell-to-cell signaling during axis determination, segmentation, and limb development with an emphasis on FGF signaling (Gao et al, Development 145: dev163824, 2018; Anderson et al., PLoS Genet. 12; e1006018, 2016; Kaltcheva et al. Dev Biol. 411:266-276, 2016). A strong background in one of the following is required: molecular biology, cellular biology or imaging technology; experience in genetics and embryology is preferred.
Cell Signaling in Vertebrate Development Section – Terry P. Yamaguchi, Ph.D. Email: firstname.lastname@example.org
Postdoctoral positions are available immediately to bright, enthusiastic and self-motivated candidates interested in studying stem cell differentiation during early mammalian development. We combine genetic, genomic, and molecular approaches with mammalian developmental and pluripotent stem cell culture systems to address the role of Wnt signaling pathways and transcription factors in gastrulation and body plan formation (e.g. Gao et al., Development 145, 2019; Kennedy et al., PNAS 113, 2016; Garriock et al., Development 142, 2015). Experience in single-cell approaches will be valued.
Regulation of Vertebrate Morphogenesis Section – Susan Mackem, M.D., Ph.D. Email: email@example.com
Molecular genetic and genomic tools (including single cell seq) are used in the lab to understand how Sonic hedgehog patterns the limb via immediate target relays and by organizing late downstream signaling centers (Zhu & Mackem, Dev. Bio. 429:391-400, 2017; Huang et al, Nature Comm.7:12903, 2016; Bowers et al, Dev. Bio.370: 110-24, 2012; Zhu et al, Dev. Cell14:624-32, 2008). Graded Gli3 repressor plays a major role in both early and late signaling centers. A post-doctoral fellowship is available immediately to investigate the molecular basis for temporal integration of this signaling network, with a focus on Gli3 roles using combined genomic and proteomic approaches, including identification of interaction partners.
Additional information about the CDBL Investigators, their research programs, publications, and contact information may be found at https://ccr.cancer.gov/Cancer-and-Developmental-Biology-Laboratory.
The CDBL labs have recently been renovated with future growth plans to accommodate two NIH Stadtman Tenure-Track Investigators. Research programs are supported by state-of-the-art core services to include; Electron Microscopy, Pathology/Histotechnology, Sequencing, Transgenics/Cryopreservation.
The CDBL is located on the NCI-Frederick National Laboratory campus at Ft. Detrick in historic Frederick, Maryland, a culturally vibrant, young and family-oriented community in close proximity to the greater Baltimore-Washington D.C urban area with easy access to the main NIH Bethesda campus and other prominent academic collaborating institutions. Recreationally, the region features mountain hiking along the Appalachian trail, snow skiing, biking, kayaking, and other water activities along the Monocacy and Potomac rivers, the Chesapeake Bay, and Atlantic seaboard.
Successful applicants must have a doctoral degree (Ph.D., MD, DDS or the equivalent) in developmental biology, cell biology, molecular biology or a related field by the start date of their fellowship and less than 5 years of applicable postdoctoral research experience. Applicants may be U.S. citizens or permanent residents; for a visiting fellowship, visa requirements apply. An NIH provided background investigation is required. Postdoctoral Trainees will receive a stipend commensurate with their experience, and benefits include an FAES health insurance plan for fellow and qualifying family.
To apply, interested individuals may email their CV, a cover letter summarizing current and future research interests, along with contact information for three references directly to the CDBL Investigator via email or by utilizing the Nature on-line submission email provided.
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