French National Centre for Scientific Research (CNRS)

Postdoctoral fellowships in cerebellar neurophysiology

Université de Paris, SPPIN, CNRS | Paris, France

Paris, France

Postdoctoral fellowships in cerebellar neurophysiology 

We are seeking multiple post-doctoral fellows for fully-funded positions at the SPPIN in central Paris (SPPIN – Saints-Peres Paris Institute for the Neurosciences, CNRS, Universite de Paris, 45 rue des Saints-Peres, Paris, France). Successful candidates will be involved in multifaceted projects dedicated to studying the role of the cerebellum in motor control using calcium imaging and electrophysiological recordings in awake, behaving animals, as well as machine learning techniques for behavioral analysis.

Proposed projects are focused on unravelling cerebellar processing in sensorimotor integration tasks : 

  1. We combine the unique expertise of two teams in the institute to break the sensorimotor loop of a simple locomotion behavior into individual sensory and motor components. We use electrophysiology and 2-photon imaging to understand how each individual component of the behavior is processed by populations of cells in the cerebellar microcircuits. We then use knowledge gained from the individual components to understand how sensory feedback interacts with motor commands in the cerebellum of awake mice running on a treadmill (PIs: B Stell and M Manuel). 
  2. The cerebellum plays a crucial role in  the timing and coordination of movements, but the cellular underpinnings of such a task remain largely unknown. Our goal is to unravel the functional role of the cerebellar molecular layer interneuron network during the acquisition of a locomotion task and adaptation to environmental changes. The results will advance our understanding of a cerebellar microcircuit and its involvement in generating coordinated movements in mammals (PI : M Graupner). 
  3. Recent work suggests that the cerebellum has a predominant role in processing cognitive and emotional aspects of behavior. We aim to study the role of the inhibitory network of the cerebellar cortex in processing reward context of a motor task by imaging molecular layer interneurons and interfering with their activity while mice are performing motor tasks with variable reward contents. The project involves collaborations with Laure Rondi-Reig and  Diego Restrepo, laboratories with extensive experience in behavioral studies and electrical and optical recordings of neuronal activity (PI : Isabel Llano). 

Applicants should hold a PhD in or related to neuroscience. The ideal candidates have practical skills for in vivo experimental work, a background in neurophysiology, and a deep desire to understand the principles underlying the functioning of the nervous system. Animal surgery, animal handling and programming skills are beneficial.

For applications we request: (i) a cover letter including a statement of motivation, (ii) a curriculum vitae, as well as, (iii) the names and addresses, including emails, of three academic references. 

Interested candidates can meet Brandon Stell at SfN 2019 in Chicago.

Project leader contacts:

Brandon Stell

Isabel Llano

Marin Manuel

Michael Graupner


Apply with CV and Cover Letter

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Postdoctoral fellowships in cerebellar neurophysiology