Washington University School of Medicine (WUSM), WUSTL

Postdoctoral Fellowship

Gilbert Gallardo

St Louis, MO, United States

Postdoctoral Research Fellow position available in Neuroscience at Washington University School of Medicine in St. Louis. The laboratory of Dr. Gilbert Gallardo, in the Department of Neurology, is recruiting multiple postdoctoral research fellows to study the cellular mechanisms of neurodegeneration of tauopathies including Alzheimer disease (AD) and to develop novel therapies for these diseases. These positions are NIH-R01 funded. We are particularly interested in studying astrocytes and neuroinflammation as several studies, including our own, are demonstrating astrocytes are a critical component of neurological disorders (Nature Neuroscience. 2014 Dec;17(12):1710-9, Nature. 2017 Sep 28;549(7673):523-527). Our studies aim at: 1) determining the extent to which mitigating reactive astrocytes are neuroprotective, 2) identifying an astrocytic mechanism that contributes to AD, and 3) identifying toxic neuroinflammatory molecules for the potential of therapeutic intervention of AD.

We also develop immunotherapeutic approaches targeting the pathological protein tau in AD and related tauopathies. Our studies, together with others, have provided compelling evidence that the tau protein is an immunotherapeutic target (J Exp Med. 2017 May 1;214(5):1227-1238, Mol. Neurodegener. 2019 Oct 22;14(1):38). The emergence of tau as a target for immunotherapy raises several fundamental questions including: 1) can we engineer immunotherapeutics optimized for tau depletion, 2) is a combination of immunotherapy with gene therapy a feasible approach for long-term treatment, and 3) does the progression of tau pathology in these diseases involve spreading of pathological tau from cell to cell via the extracellular space in the brain? To answer these questions we have engineered a series of single-chain fragment variables (scFVs) directed against human tau. These anti-tau scFVs serve as molecular tools for engineering immunotherapeutics optimized for tau depletion.

Candidates must hold a Ph.D. or M.D. and should have a strong background in molecular/cellular biology and experience in handling animal models. A track record of productivity with peer-reviewed publications, excellent organizational skills, fluent English, and less than 2 years of prior postdoctoral experience are required.

Qualified applicants are invited to submit a letter of application and their curriculum vitae including the names and contact details of three references to gallardog@neuro.wustl.edu or carolynmann@wustl.edu   

Washington University School of Medicine in St. Louis is an equal opportunity, affirmative action educator and employer.

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Position

Postdoctoral Fellowship