Two new post-doctoral positions available in the Strittmatter laboratory to study the mechanisms of neurodegeneration in Alzheimers disease and related disorders. The goal is to define pathophysiological mechanisms with an emphasis on identifying targets for therapeutic intervention to halt degeneration, and on achieving neural repair after either degenerative or traumatic CNS injury. Three projects have transitioned from bench discovery to clinical trials. These experiments are robustly supported by grants from the NIH including R35NS097283, RF1AG070926, R01AG066165, R01AG034924, U01AG058608 and P30AG066508.
Discovery techniques being applied include snRNAseq expression profiling of mice models and human brain tissue, lab-dedicated Stellaris STED imaging of synaptic structures, single particle cryo-EM of purified synaptic protein complexes, expression cloning of novel receptors, and CRISPR gene editing in neurons and in mouse brain.
The optimal candidate will have a track record of productive neuroscience research using molecular cell biological and/or protein chemistry approaches documented in peer-reviewed publications. Familiarity with R is preferred. We seek a passionate post-doctoral Fellow who has the capacity to work independently but also thrives in a diverse team environment. The shared long-term goal is apply modern neuroscience to solve neurological problems. MD, PhD or MD/PhD required.
Applicants should send CV with the names of three references to <firstname.lastname@example.org>.
Yale University is an Affirmative Action/Equal Opportunity employer. Yale and the Strittmatter laboratory highly value diversity amongst our personnel, and we encourage applications from women, persons with disabilities and underrepresented minorities.