University of Washington (UW)

Postdoctoral Fellow

University of Washington (UW), United States

Seattle, WA, United States

Open Postdoctoral and Research Scientist Positions in the Yang Lab

 

The Yang lab at the University of Washington Department of Medicine/Cardiology, which collaborates closely with Dr. Chuck Murry’s research group, is seeking up to two postdoctoral researchers with an interest in using induced pluripotent stem cells (iPSCs) to model genetic cardiomyopathies due to sarcomeric mutations. Although postdoctoral candidates are preferred, research staff scientists will also be considered.

 

The Yang lab has two major focuses. The first is to use patient-specific and gene-edited iPSC-derived cardiomyocytes to rapidly study multiple myosin heavy chain 7 variants and then phenotype them with high-throughput functional assays. A large number (on the order of thousands) of variants will be generated with cutting-edge gene-editing techniques in collaboration with our colleagues in Genome Sciences. As sarcomeric mutations act as poison peptides, the second focus of the lab is to understand the mechanisms that regulate the clearance of mutant sarcomeric proteins in order to leverage this knowledge for possible therapeutic potential. This involves innovative confocal microscopy techniques that the lab has developed to measure sarcomeric dynamics along with gain-of-function and loss-of-function experiments to study the role of key sarcomeric regulators in genetic cardiomyopathies.

 

These are highly collaborative projects that will expose the successful candidate to collaborators in Cardiology, Genome Sciences, Institute for Stem Cell and Regenerative Medicine (ISCRM), and Bioengineering. This position will be primarily supervised by Dr. Yang but will also have the opportunity to be co-mentored by Dr. Murry.

 

Requirements: MD or recent PhD in molecular biology, cell biology, genetics, bioengineering or related field. There are no citizenship or permanent residency requirements.

 

Highly motivated candidates with first-author publication(s) are encouraged to apply. If interested, please upload a cover letter with research interests, CV, and contact information for three referees by email to Interfolio.

 

For additional information and link to the Yang and Murry lab websites, please visit:

https://cardiology.uw.edu/faculty/daniel-yang-md

http://www.pathology.washington.edu/research/labs/murry/index.php?a=welcome&p=main

 

Application

If interested, please apply at the following links:


Postdoctoral Fellow:

https://apply.interfolio.com/73359


Research Scientist: https://uwhires.admin.washington.edu/ENG/Candidates/default.cfm?szCategory=jobprofile&szOrderID=176091


Please apply via recruiter’s website.