Postdoctoral Fellow

Susan Bellis

Birmingham, AL, United States

A postdoctoral position is available in the Bellis laboratory to study molecular mechanisms that drive pancreatic cancer. Specifically, my group has developed a transgenic mouse model that exhibits greatly accelerated pancreatic cancer progression due to the overexpression of the ST6Gal-I glycosyltransferase.  The ST6Gal-I enzyme adds the sugar, sialic acid, to key receptors involved in cell signaling and thereby regulates tumor cell behavior. Using this mouse model, along with patient samples and organoid lines, we are investigating the role of tumor glycans in imparting a cancer stem cell phenotype and promoting immune escape. We are also studying the effects of ST6Gal-I-bearing exosomes in remodeling the tumor microenvironment.

 

This position requires a recent Ph.D. degree and broad training in cell and molecular biology, as well as experience with genetically-engineered mouse models. Expertise in cancer biology and genome editing are preferred, but not required. Interested applicants should submit a CV which includes contact information for three references, and a cover letter summarizing research accomplishments, to Dr. Susan Bellis, bellis@uab.edu

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Position

Postdoctoral Fellow