Postdoctoral Fellow - type 1 diabetes research (f/m/d)

Helmholtz Zentrum München - German Research Center for Environmental Health (HMGU)

München, Germany

Work group:

Institute of Diabetes Research Type 1

Area of research:

Scientific / postdoctoral posts

Starting date:


Contract time limit:


Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

The research focus of the Institute of Diabetes Research (Helmholtz Zentrum München) lays in understanding the pathogenesis of type 1 diabetes, in identifying mechanisms and predictive markers of the disease, and the translation of findings into trials to prevent type 1 diabetes in humans. The Institute is particularly interested in deciphering the molecular mechanisms of islet autoreactivity, and the interaction of environment, genes, and the immune response. The ultimate goal is to develop therapies for the prevention and cure of islet autoaimmunity and diabetes. The Institute of Diabetes Research is part of the Helmholtz Diabetes Center and the German Center for Diabetes Research.

The type 1 diabetes pathology group headed by Dr. Teresa Rodriguez-Calvo is looking for a highly motivated postdoctoral fellow to join a collaborative group studying proinsulin processing and immune recognition in type 1 diabetes. The project will use samples provided by the Network for Pancreatic Organ Donors with Diabetes (nPOD), which collects pancreas tissue samples from healthy and diabetic organ donors and distributes them to researchers around the world in order to answer basic questions regarding the pathogenesis of type 1 diabetes.

Postdoctoral Fellow – type 1 diabetes research (f/m/d)

Job description

We are looking for a highly motivated Postdoc to work independently and help us to study the interaction between the immune system and insulin-secreting beta cells. The selected candidate will have access to state of the art microscopy techniques, including super-resolution microscopy, which will allow us to determine the expression, cellular localization and processing of proinsulin in beta cells. The project will utilize advance image analysis, combining machine-learning algorithms with automated software analysis. In addition, the selected candidate will study how immune cells recognize proinsulin and investigate the presence of proinsulin-specific cells in the pancreas.

The ultimate goal of this exciting postdoctoral project is to develop novel biomarkers and therapeutic approaches targeting beta cell dysfunction possibly in combination with antigen specific therapies.

As a postdoctoral fellow in our lab, you will collaborate with team members in Germany and USA, with international researchers within the Network for Pancreatic Organ Donors with Diabetes and with other investigators around the world who share similar research interests and goals. You will be required to efficiently plan and optimize experiments using various techniques, including immunofluorescence and microscopy to answer key questions in type 1 diabetes pathogenesis and present quantitated data at scientific meetings.

Your qualification

Applicants (Ph.D., MD/Ph.D.) must have a strong background in immunology and cell biologyPrevious experience in flow cytometry, histology and microscopy along with some background in type 1 diabetes research is highly desirableA high degree of computer skills is required. Programming skills in Java, R and/or Python is highly desirableExperience in image and data analysis is a plusGood verbal and written communication in EnglishTeam player and enthusiasm to work in a multi-disciplinary and collaborative environmentAbility to work independently and with others within an outstanding scientific environment is a mustInternational experience is an advantage

What we offer you

A challenging and versatile field of work providing you with the freedom to follow your instinct and be creative. With the help of extensive and goal-orientated professional development measures and career-building programmes we encourage you to grow as a person. To ensure a good work/life balance we assist you with flexible working hours, in-house health management, a nursery, and an “Elder Care” concept as well as other consultation and support options.

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and research institutes it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund).

The position is (initially) limited to two years, but under certain circumstances an extension can be arranged.

The activity involves special knowledge and experience specific to own scientific skills.

As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.

Curious? If you have further questions, simply contact Dr. Rodriguez-Calvo  by phone +49 89 3187 1578 but do not forget to also apply online through the link below.

We are looking forward to receiving your online application including a letter of motivation and CV in English.

Please apply via recruiter’s website.

Quote Reference: 2019/0412