The Children's Hospital of Philadelphia (CHOP)

Postdoctoral fellow – Ribosome biogenesis and ubiquitin signaling in stem cells

University of Pennsylvania School of Medicine/ Children's Hospital of Philadelphia

Philadelphia, PA, United States

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to investigate ribosome biogenesis and ubiquitin signaling in hematopoietic stem cells. Dr. Tong’s laboratory studies ubiquitin signaling in hematopoietic stem cells, bone marrow failure, and leukemia. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. The Tong laboratory found a novel E3 ubiquitin ligase that plays a critical role in ribosome biogenesis and thereby controls hematopoietic stem cell activity. This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Our recent publications include: Nature communications 9(1): 3915, Sep 2018; Genes & development 31(10): 1007-1023, May 2017; Blood 133(14): 1560-1571, Apr 2019. You can find more of our recent publication and laboratory information in below website.

https://www.med.upenn.edu/apps/faculty/index.php/g20000220/p8146029

Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, molecular biology, as well as mouse models.

Highly motivated candidates with publication records are encouraged to apply. Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to:

tongw@email.chop.edu

Key words:
leukemia, signaling, hematopioetic stem cells, kinase, ribosome, ubiquitin

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Position

Postdoctoral fellow – Ribosome biogenesis and ubiquitin signaling in stem cells