Princess Margaret Cancer Centre, U of T

Postdoctoral Fellow

Princess Margaret Cancer Centre, U of T

Toronto, Ontario, Canada

Postdoctoral Position in Head and Neck Cancer Modeling

Princess Margaret Cancer Centre/Structural Genomics Consortium/University of Toronto

POSTDOCTORAL position is available at the University of Toronto, in partnership with the Princess Margaret Cancer Centre and the Structural Genomics Consortium. The goal of the project is to develop and optimize patient-derived models of head and neck squamous cell carcinoma (HNSCC). The applicant will derive and optimize novel in vitro models that incorporate multiple cell types from primary tumor tissues (e.g. cancer cells, fibroblasts, immune cells). In addition, assays to explore the key aspects of HNSCC growth, invasion, immune responses and potential of therapeutic modulation will be developed and utilized to screen well characterized small molecule inhibitor/probe libraries. The combined cancer cellular models and chemical biology approach will enable identification of key pathways driving tumorigenicity, invasion, and immune responses, as well as discovery of new therapeutic strategies.

Outstanding and highly motivated candidates are invited to apply. Candidates with the following experience or research interest are preferred:

·        Strong experimental skills in: primary cell culture, molecular biology, phenotypic screening.

·        Additional skills in high throughput cellular screening, live cell imaging and computational data analysis would be an asset.

·        Experience working in multidisciplinary environment.

·        Strong organizational, team and communication skills.

We are looking for an independent individual, who strives for a next position on an academic career path or independent Staff Scientist. The ideal candidate will be highly motivated, have obtained his/her Ph.D. within the last three years and possess the ability to work independently and in a team environment.

This position is a two-year term appointment, commencing as soon as possible. To apply, please send curriculum vitae, a brief description of your career expectations, and contact information for three references directly to Dr. Laurie Ailles ( 

Closing date: The competition will remain open until the position has been filled.

The Princess Margaret Cancer Centre is the largest integrated cancer research, teaching and treatment centre in Canada, and one of the largest cancer clinical trials centres in the world. Cancer research is a priority at the Princess Margaret, where researchers employ state-of-the-art tools in genomics, proteomics, structural biology, cell biology, molecular biology, biophysics and the behavioural sciences to address scientific questions related to cancer and improving the lives of cancer patients.

The SGC is a not for profit, public-private partnership working with academia and pharmaceutical companies to carry out open access basic science relevant to human health and drug discovery.                    


The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.

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Postdoctoral Fellow