Institute of Cancer Research (ICR)

Postdoctoral Fellow, Priming T cell responses (Prof Alan Melcher)

Institute of Cancer Research (ICR)

London, United Kingdom

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has not yet been awarded their PhD, the starting salary will be at £32,844 until the successful completion of their viva.

Duration of Contract: Fixed Term until 31st July 2025

Hours per week: 35 hours per week (Full Time)

Closing Date: 3rd July 2022 

Job Details

Research Lead: Professor Alan Melcher 

Summary of Role

We are seeking a creative and motivated Postdoctoral Training Fellow to study the activation of human anti-tumour T cell responses using pre-clinical in vitro assays. This post will focus on the molecular biology of characterising and testing the immunogenicity of specific breast cancer target proteins and peptides in human naïve and recall T cell priming assays. The successful candidate will investigate in detail functional T cell responses, and the TCR repertoire of the primed cytotoxic T cells. They will also expand on previous work within the group on oncolytic virus and mRNA-based vaccination strategies, developing alternative therapeutic vaccination strategies against these targets. This project will link closely to other team members looking at complementary murine model systems, and studying samples collected from patients. This post will be strategically linked to Breast Cancer Now-funded research in immunology and immunotherapy at KCL, with which there will be close interaction.

This position is offered on a fixed term contract until July 2025 in the first instance. Starting salary is in the range of £32,844* to £41,718 per annum inclusive based on previous postdoctoral experience.

*thesis submitted, awaiting PhD award

Key Requirements

The successful candidate must have knowledge of cancer biology and cancer immunology as well as a strong record in biomedical research as demonstrated by high-impact, first author publications.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years

Department/Directorate Information:

The Breast Cancer Immunology team is led by Alan Melcher and looks at ways to activate the immune system to attack breast cancer using therapeutic oncolytic viruses, radiotherapy, targeted drugs and combination strategies. The agents we prioritise are already in clinical use and offer major potential benefits to further improve the promising field of immunotherapy. We use a range of mouse and human pre-clinical assays to test the immune response following our interventions.

The Breast Cancer Immunology team is part of the Division of Breast Cancer Research and sits within the Breast Cancer Now Toby Robins Research Centre at the ICR, the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. The Breast Cancer Immunology team collaborates with the Breast Cancer Now Research Unit based at King’s College London (KCL).

 We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Pip Wilkinson vis email on pip.wilkinson@icr.ac.uk

About The Institute of Cancer Research

Why work for us?

As a member of staff, you’ll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

Please apply via recruiter’s website.