TB remains a serious global health problem and there is an urgent need for new therapeutic agents and an increased understanding of antibiotic resistance. The Parish Lab is looking for a post-doctoral scientist to work on a tuberculosis drug discovery project. The successful candidate will work in a multi-disciplinary research environment interacting with chemists and biologists. The main research project is to determine the mode of action of new compounds classes under development as TB drugs. Work will also involve target identification, confirmation, and validation, as well as determining mechanisms of drug resistance.
Description of Responsibilities:
- Conduct a research and development project
- Design and implement research plans
- Work under Biosafety Level 3 conditions with Mycobacterium tuberculosis
- Troubleshoot and solve experimental and technical problems
- To prepare and present papers, reports, and presentations of current research work
- Write manuscripts and assist with grant preparation
- Write standard protocols and validation data packages
- Oversee quality control and data integrity
- May supervise one or more research assistants
Specific duties include:
- Conduct research into mechanism of kill of new inhibitors
- Use multiple approaches to identify and validate drug targets
- Research into mode of resistance of new inhibitors
- Run a wide range of microbiological and cellular assays
- Culture and genetic manipulation of mycobacteria
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