Chronic pain is a highly prevalent neurological condition, affecting 30% of the US population. The recent epidemic of opioid related deaths has drawn attention to the lack of effective non-addictive pain treatments available. The goals of this project are to determine the molecular and cellular organization of mouse and primate (human and non-human) spinal cord dorsal horns and to use this information to investigate the functional neural circuitry underlying chronic pain.
Our laboratory has been investigating the neural circuitry for chronic pain in mice (See Moehring et al, Neuron, 2018, Peirs and Seal, Science, 2016 and Peirs et al, Neuron, 2015) and we are now extending these studies to develop treatments that target chronic pain in humans. The successful candidate will design and perform experiments to identify the neural circuitry for chronic pain using cutting-edge approaches such as single cell or nucleus sequencing, ATAC-seq, bioinformatic analysis, barcoded library screens, viral injection of designer receptors, behavior and histology.
The training experience of the successful candidate will be further enhanced by being a member of the Pittsburgh Center for Pain Research (see http://www.paincenter.pitt.edu/), which holds weekly journal club, bimonthly research in progress presentations, monthly seminar series and courses on pain. Presentations at national and international meetings, authorship on manuscripts, reviews and grants as well as the option to mentor undergraduate student in laboratory work is also part of the training experience.
PhD or MD in neuroscience, physiology, molecular or related discipline. Candidates with experience in molecular techniques and/or bioinformatics are especially encouraged to apply.
Creative thinking skills, command of the neuroscience literature, affinity for performing experimental animal research and ability to work collaboratively with excellent communication skills are desired.
ABOUT THE EMPLOYER
The Seal laboratory is located in the Department of Neurobiology in the School of Medicine and is part of the large, vibrant, multidisciplinary, and internationally recognized neuroscience community, which also includes Carnegie Mellon University. The University of Pittsburgh is currently ranked third in NIH funding and is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EEO/AA/M/F/Vets/Disabled.
ABOUT THE CITY
Pittsburgh offers numerous cultural and sports activities as well as an affordable lifestyle for young professionals and is ranked second most livable in America according to The Global Livability Index 2018.