Massachusetts General Hospital

Postdoctoral Fellow in Tumor Immunology

The Mempel Lab

Boston, MA, MA, United States

The Mempel laboratory in the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital and Harvard Medical School is seeking a highly motivated postdoctoral fellow to study the epigenetic control of regulatory T cell (Treg) stability in tumor tissue. Our lab’s recent findings indicate that inhibition of the CARMA1-BCL10-MALT1 pathway destabilizes Treg and selectively in the tumor microenvironment reprograms these cells into anti-tumor effector cells that express pro-inflammatory cytokines. (Di Pilato M et al, Nature, 2019). We are seeking a PhD or MD/PhD scientist with a background in genomics approaches (e.g. ChIP-seq, bisulfite-seq etc.) and an interest in T cell biology and tumor immunology to lead follow-up studies to identify the environmental triggers and molecular mechanisms of Treg instability and pro-inflammatory gene expression. The goal of these studies is to discover novel approaches for cancer immunotherapy.


The ideal candidate has a strong background and experimental expertise in cellular and molecular immunology, including in genomics approaches and in in vivo mouse studies. Both national and international candidates are encouraged to apply, but a documented track record of significant prior scientific achievement in the field of immunology or closely related disciplines is required.


Applicants should submit 1. a cover letter describing their previous scientific accomplishments and interests and career goals, 2. their C.V. and 3. contact information for three references via e-mail to Thorsten Mempel, MD, PhD: tmempel@mgh.harvard.edu

Favorite

Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB
Position

Postdoctoral Fellow in Tumor Immunology