National Institutes of Health (NIH)

Postdoctoral fellow in neurogenetics

National Institutes of Health (NIH)

Bethesda, MD, United States

Laboratory description:

The Neurodegenerative Diseases Research Unit (NDRU), part of the Laboratory of Neurogenetics within the National Institutes of Health, is recruiting a postdoctoral fellow. The Laboratory of Neurogenetics is a genetics laboratory within the Intramural Research Program in Bethesda, MD, USA with an exemplary track record in gene discovery for neurodegenerative diseases, including LRRK2, C9orf72, and TREM2, among others. As part of this world-class research environment, we have access to cutting-edge sequencing technologies and extensive expertise in genome analysis and human genetics. Our mission is to understand how genetic changes influence the risk of developing complex neurodegenerative diseases. We also aim to use genetic knowledge for the development of novel ancillary diagnostic tools. We specialize in applying modern gene discovery technologies, including genome-wide association testing, genome sequencing, and genomic data integration.


Position summary: We are searching for a highly collaborative and inquisitive scientist to join our team. This position is a full-time, post-doctoral fellowship that requires previous experience in genetics. The successful applicant is expected to design, execute, and analyze large-scale genomic experiments, such as genotyping and next-generation sequencing applications, and to assist in the project management and analysis of large genomic datasets. Aside from wet lab experience, the applicant is expected to mine clinical and genetic datasets, perform association analyses and supervise research technicians. The post-holder is expected to read the pertinent literature, write peer-reviewed research articles, and deliver her/his research findings to international audiences in the field of neurogenetics. Upon successful completion of the fellowship, the applicant will be able to design, execute, analyze, and lead large-scale genomics projects.


Key requirements:

·      M.D. or Ph.D. in a relevant life science discipline (applicants who have submitted their PhD thesis and are awaiting their PhD award are also encouraged to apply)

·      Experience with experimental genetic design and classical statistics is required

·      Experience in commonly used gene discovery strategies (e.g., GWAS, segregation analysis, candidate gene analysis, etc.) 

·      Experience with analyzing and reviewing publicly available data (e.g., Human Gene Mutation Database, dbGaP, GnomAD, etc.) 

·      Basic scripting (bash, python, R), statistical and visualization skills

·      Excellent analytical, organizational and time management skills

·      Strong communication and presentation skills, both oral and written

·      Ability to work to tight deadlines

·      Ability to work as part of a team is essential


Salary is commensurate with research experience and accomplishments. Interested candidates should contact Dr. Sonja Scholz (e-mail: sonja.scholz@nih.gov). Please provide an updated CV, a cover letter and three references in your application.


The NIH is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.

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Position

Postdoctoral fellow in neurogenetics