Icahn School of Medicine at Mount Sinai (ISMMS), MSHS

Postdoctoral Fellow in Lung Cancer Epigenomics

Icahn School of Medicine at Mount Sinai (ISMMS), MSHS

New York, NY, United States

One postdoctoral position for talented and enthusiastic scientist is available in the Watanabe laboratory at Icahn School of Medicine at Mount Sinai. This position provides a unique opportunity to train in the outstanding scientific and collaborative environments at Icahn School of Medicine at Mount Sinai in the Department of Medicine, as well as the interdisciplinary Tisch Cancer Institute.


Watanabe laboratory’s goals is to utilize epigenomics and state-of-the-art technologies to characterize various cellular lineages in normal lung as well as in lung cancer subtypes and identify and elucidate the mechanism of the lineage programs that are aberrantly fixated in lung cancer. We explore the hypothesis that different subsets of lung cancers mimic and depend upon certain differentiation programs, and rely on existence of enhancer clusters for transcription factors driving such programs, and those tumors represent a heterogeneous population of distinct lineages, influenced by genomic contexts and/or microenvironment, as well as influencing the effects of genomic contexts.


We seek to understand 1) what cellular identity the tumors cells may arise from or acquire during carcinogenesis, 2) how they maintain and may depend upon the identity once established, 3) how they may shift identity upon survival pressure from micro-environmental changes or drug treatment, and 4) how mixed populations within a tumor may interact with each other to maintain the tumor as a community over the time of tumor evolution.


http://labs.icahn.mssm.edu/watanabelab/


Qualifications and Experience

The successful applicant will hold a doctoral degree or equivalent qualification in biological science with demonstrated experience in genomics. Expertise in genomic analysis, single-cell genomics and statistical interpretation and analysis of next-generation sequencing is preferred.


We especially seek candidates with prior experience in genomic or epigenomic applications. A solid knowledge in cell culture, sample preparation, molecular biology and quantitative biology is preferred. The ideal applicant should have demonstrated the ability to work independently and creatively. (S)he should have excellent communications skills and be able to articulate clearly the scientific and technical needs, set clear goals and work within an interdisciplinary setting, communicating with other partners within the collaborations.


Duties & Responsibilities:

Experiments

Communication

Support for mentoring, funding opportunities


Application Instructions

Interested applicants should email 1) Cover letter, 2) Biosketch or CV and 3) A list of references in a single PDF to hideo.watanabe@mssm.edu.

 


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Position

Postdoctoral Fellow in Lung Cancer Epigenomics