Postdoctoral fellow in Immunometabolism
3 year fixed-term contract (with possible extension to four years), full time, start date October-November 2019
In the past years multi-omics analysis of inflammatory bowel disease (IBD) has painted a multifaceted picture of this complex immune-mediated disorder. A thorough understanding of the molecular causations that lead to manifestation and result in pathological cytokine signalling is still lacking.
This specific project carried out at LIH will be part of a bigger consortium effort, funded by the highly competitive eMED-BMBF program. The consortium consists of a clinician (patient cohorts, patient based organoid in vitro models, functional analyses and generation of different omics datasets) and a physicist (development of novel tracers for MRI) from the University Hospital in Kiel, Germany and a systems biologist from the Institute of Computational Biology at the Helmholtz Centre Munich, Germany.
Here in Luxembourg, we will work with patient derived biosamples (blood, stool, biopsies) and patient derived organoid models to study the immune-metabolic crosstalk in IBD. Knowledge transfer and training opportunities both in Kiel and Luxembourg will be provided. At LIH, the experimental work will focus on the quantitative analysis of mammalian metabolism (including stable isotope-assisted metabolic flux analysis). The analyses will be combined with molecular – and cell biology techniques (Western Blot, qPCR, FACS, IF). We will focus on the metabolism of myeloid cells and its interplay with the intestine in the context of IBD.
The overarching goal of this consortium effort is to integrate a focused metabolic understanding into multi-omics models to elucidate pathophysiological key features of immune-metabolic crosstalk in IBD.
The successful candidate will be embedded in a state-of-the-art laboratory at the Department of Oncology composed of more than 85 staff members. The Cancer Metabolism team headed by Johannes Meiser and core funded by the FNR ATTRACT program currently consists of two PhD students and one Postdoctoral fellow.
Relevant publications: Meiser et al., 2016, Science Advances; Meiser et al., 2016 Journal of Biological Chemistry; Nikolaus et al., 2017 Gastroenterology; Meiser et al., 2018 Oncotarget; Aden et al., 2018 JExpMed.
Key Skills, Experience and Qualifications
• Successful PhD in the area of biology, systems biology or biotechnology
• Hands-on experience in experimental lab work including the use of mammalian cell models
• Experience in metabolism and Mass Spectrometry and a keen interest to gain proficiency in this area
• Experience in the field of immunology
• Computational skills (using R, MATLAB or similar) are not required but can be a plus
• Open minded, self-driven and curious person, willing to work in a competitive, interdisciplinary and international environment
The position will be accompanied by training and mentoring opportunities to get prepared for the next career step in becoming an independent researcher.
For any further information, please contact Dr. Johannes Meiser : email@example.com
Publication record: https://scholar.google.de/citations?user=1Kt1jDkAAAAJ&hl=de
Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual
environment that values personal respect and professional achievement based on the highest intellectual and ethical standards.
Applications including cover letter, CV, list of publications and name of two referees should be sent before 31 July 2019 through our website www.lih.lu/jobs with the Ref: VD/PDIMM0619/JM/LRNO NB.