Ragon Institute of MGH, MIT and Harvard

Postdoctoral Fellow in Immunology/Molecular Biology

Ragon Institute of MGH, MIT and Harvard

Bethesda, MD, United States

A postdoctoral fellow position is available in Dr. Mary Carrington’s laboratory (http://www.ragoninstitute.org/portfolio-item/carrington/) to study the influence of immunogenetics on human disease, and the functional bases for those associations. We are interested in defining novel characteristics of HLA that impact their function beyond peptide binding.  Our group examines immunogenetic associations in a large variety of diseases including cancer, transplantation outcome, autoimmune and infectious diseases, and the elucidation of the molecular mechanisms of these associations. We have found that HLA alleles vary in their expression levels and their dependence on the peptide loading complex to an extent that modulates the efficacy of the immune response. We are also in the process of carrying out in-depth genetic studies of the antigen processing machinery components to determine their influence on peptide repertoire breadth and HLA-peptide complex stability on the cell surface. These efforts are strongly supported by our computational group, who apply statistics, bioinformatics, and molecular evolution methods to the genetic and biological work performed in the lab. The lab seeks to recruit a bright, highly motivated and creative postdoctoral fellow with experience in molecular biology, cellular biology, and/or genetics to join our multidisciplinary team. The successful candidate will be expected to plan, design and perform experimental work, manage research projects, prepare papers for publication and presentation, and work collaboratively while developing the skills needed to become an independent scientist. Experience in cell culture, flow cytometry, molecular biology is essential, and knowledge of NK cell biology and HLA immunogenetics is highly desirable.

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Position

Postdoctoral Fellow in Immunology/Molecular Biology