Postdoctoral Fellow in Cancer Immunology
One postdoctoral position is available in the laboratory of Dr. Israel Cañadas at Fox Chase Cancer Center (Philadelphia, PA). The Cañadas Lab studies tumor immunity and the tumor microenvironment in lung cancer with the ultimate goal of identifying new therapeutic opportunities to improve patient health.
We are primarily interested in delineating mechanisms of tumor resistance to immunotherapy, and in leveraging innate immune signaling pathways to break therapy resistance and restore immunogenicity. We have recently identified a novel family of endogenous retroviruses (ERVs) which, when reactivated in lung tumor cells, engages innate immune signaling pathways and stimulates adaptive anti-tumor immune responses (Cañadas et al, Nat Med, 2018). Projects in the lab will include (1) deciphering the mechanisms of ERV silencing and reactivation at the epigenetic level; (2) study of cytosolic nucleic acid-sensing pathways in the context of innate and adaptive antitumor immunity; and 3) use of novel functional ex vivo organotypic 3D culture platforms using surgically resected murine and patient-derived tumor samples to identify and characterize mechanisms of response and resistance to immune checkpoint inhibitors.
The Cañadas lab is located at Fox Chase Cancer Center, a NCI-designated comprehensive cancer center and consistently ranked as one of the best places for postdocs to work, with state-of-art research facilities and a multidisciplinary research environment that provides unique and outstanding training and collaborating opportunities.
The ideal candidate will hold a recent Ph.D., with a background in cancer biology/genetics and immunology, as evidenced by first-author publications. Prior experience in molecular/cellular biology and cell culture assays will be essential. Familiarity with CRISPR-based approaches, fluorescence microscopy and in vivo cancer models is an advantage. Successful applicants will have the opportunity to work in a translational research program that encompasses from basic science discoveries to clinical applications.
To apply for this position, please send your CV, a cover letter stating research interests, and names of three referees to:
Blood Cell Development and Function Program
Fox Chase Cancer Center
Reimann Building 362
333 Cottman Ave.
Philadelphia, PA 19111