German Cancer Research Center in the Helmholtz Association (DKFZ)

Postdoctoral Fellow in Cancer Genetics & Molecular Biology

German Cancer Research Center in the Helmholtz Association (DKFZ)

Freiburg im Breisgau, Germany

The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

For the partner site of DKTK Freiburg im Breisgau the German Cancer Research Center is seeking a

Postdoctoral Fellow in Cancer Genetics & Molecular Biology
(Ref-No. 2020-0046)

Our research division explores the molecular mechanisms underlying carcinogenesis with a special emphasis on non-canonical and novel types of mutations in cancer (EMBO Mol Med 2016, Nat Commun 2019, Nat Cell Biol – in 2nd revision). The method spectrum in our lab ranges from innovative techniques from molecular and cell biology like diverse CRISPR techniques (Nucleic Acids Res 2017, Hepatology 2018) or RNA-Protein complex identification (Nature 2015, Mol Cell 2019, Nat Protoc 2020) to applications in bioinformatics and biochemistry. Our lab in Freiburg is newly equipped with state-of-the-art instrumentation.

We are seeking a highly motivated, ambitious postdoctoral fellow with significant and published experience in the area of molecular biology and / or cancer research, ideally in cancer genetics. The core project of the postdoctoral fellow will be the functional characterization of non-canonical genetic alterations in cancer in higher through-put. Research questions will include their impact at the cellular and molecular level on mRNA and protein expression and their mechanistic impact. An innovative screen using CRISPR site-directed mutagenesis shall unravel their impact on human cells. Comprehensive resources as well as established protocols to build on are available. Jointly with the division head, new projects within the focus area of the lab can also be developed and supported to allow the growth into scientific maturity and independence.

Your profile:
You are a highly motivated postdoctoral fellow with a PhD / Dr. rer. nat. in a life science field and are eager to pursue and lead research projects in tumor genetics and the molecular biology of cancer including high through-put approaches and genome editing with ambition, creativity, independence and team spirit. You have published experience in techniques of cellular and molecular biology or cancer research. Practical knowledge of bioinformatics would be welcome. You work efficiently, goal-oriented and accurate, have a deep interest in research and are proficient in English.

The position is limited to 2 years.

The position can in principle be part-time.

For further information please contact
Prof. Dr. Sven Diederichs, phone +49 761 270-77571.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Please apply via recruiter’s website.

Quote Reference: Ref-No. 2020-0046