Western Michigan University (WMU)

Post-Doctoral Fellow - Immunobiology Rothstein Lab

Western Michigan University and Homer Stryker M.D. School of Medicine

Kalamazoo, MI, United States

Post-Doctoral Fellow – Immunobiology Rothstein Lab
Western Michigan University Homer Stryker M.D. School of Medicine

Overview:
The Center for Immunobiology of the Western Michigan University Homer Stryker M.D. School of Medicine invites applications for a Post-Doctoral Fellow research position in the laboratory of Thomas L. Rothstein MD, PhD, Director of the Center for Immunobiology. Responsible for providing ongoing projects for molecular immunology include: B1 cell development and function, including the role of human B1 cells and natural antibody in health and disease; BCR signaling pathways including receptor crosstalk and the IL-4-induced alternate pathway; B cell pathogenesis in lupus, rheumatoid arthritis, and other autoimmune dyscrasias.; B cells and aging, including atherosclerotic and infectious diseases.

Responsibilities:
• Direct involvement and participation in discovery-based research
• Communicates problems or matters of a scientific, technical and/or administrative nature both within the department and interdepartmentally utilizing computer technology
• Conducts independent research and assists in the conduct of research
• Analyzes data and interprets results to write reports and summaries of findings
• Maintains accurate records of tests conducted, results, data and patients tested including calculation of results from supplied data, obtained data and statistics
• Provides instruction in laboratory technique, instrumentation, and application of laboratory test procedures to new technicians and students
• Assists supervisor and lab members in the development of technical procedures and protocols
• Organizes and prioritizes work to meet specific goals and accomplishments
• Manages lab technicians time
• Provides feedback to lab members and department managers
• Maintains clean and efficient work area and replenishes supplies as necessary.
• Conducts isolation and in vitro culture of primary lymphocytes
• Conducts various assays on purified populations including immunoflorescent staining
• Conducts RNA isolation/RT-PCR, expression cloning, protein extraction, western blotting
• Prepares stock solutions and reagents
• Is available to work occasional overtime on weekends or evenings to complete time sensitive projects.
• Acquires knowledge for new technology and policy/procedure revisions.
• Pursues all other duties as assigned.

Qualifications:
• PhD in immunology, microbiology, biochemistry, or molecular biology
• Required skills include experience with: sterile tissue culture, immunofluorescent staining, flow cytometric analysis, RNA, DNA and protein extraction, vertical and horizontal gel electrophoresis, protein immunoprecipitation, Western blotting, polymerase chain reaction, and molecular cloning.
• Demonstrates the ability to recognize priorities in organization of work flow
• Able to perform duties independently, with a minimal need for direct supervision

About the Center for Immunobiology
The Center for Immunobiology is new division within the medical school. The Center is endowed with the very latest instrumentation to speed research discovery. Common equipment includes BD Influx and Melody cell sorters, BD Fortessa and Thermo Fisher Attune flow cytometers, a Nikon confocal microscope, an Applied Biosystemi SeqStudio Sanger sequencer and an Illumina MiSeq sequencer, a 10XGenomics platform, a QuantStudio 3D digital PCR system, a QuantStudio 3 RealTime PCR cycler, a Bio-Rad FPLC system, a Bio-Rad gel doc system, a CTL multi-spectral ELISPOT reader, a BioTek visible/fluorescence/bioluminescence microplate reader, a BioTek microplate washer, 2 speedvacs, several bacterial incubator shakers, and ultra-, superspeed, and cytospin centrifuges, among other items. Three separate, fully equipped common rooms are outfitted for BL2, radioisotope, and tissue culture work. Additional separate rooms house core equipment, freezers, and an X-ray developer. The Center floor includes a cold room, a conference room, and a break room. The animal facility is located on the same floor and contains a PXi X-RAD 320 irradiator and a BL2 room for in vivo work with infectious agents. Support for the Center includes a flow cytometer/cell sorter/imaging core manager, a sequencing core manager, and a business and operations manager.

About Western Michigan University Homer Stryker M.D. School of Medicine
As one of the newer US medical schools, WMed is an exciting environment to pursue an academic career. The medical school is a collaboration of Western Michigan University and Kalamazoo’s two teaching hospitals, Ascension Borgess Health and Bronson Healthcare. The medical school is a private 501©(3) nonprofit corporation supported by private gifts, clinical revenues, research activities, tuition, and endowment income. WMed is fully accredited by the Liaison Committee on Medical Education (LCME) and also by the Higher Learning Commission (HLC). The inaugural medical student class graduated in 2018 after completing an innovative, patient-centered four-year curriculum that prepares them to be exceptional clinicians, leaders, educators, advocates, and researchers of tomorrow. There are more than 200 residents and fellows in ten residencies and three fellowships accredited by the Accreditation Council for Graduate Medical Education (ACGME). WMed has Joint Accreditation for interprofessional continuing education, which incorporates accreditation by the Accreditation Council for Continuing Medical Education (ACCME). The School of Medicine Clinics are housed in a modern 60,000 square foot clinical building on the Oakland Drive Campus and are accredited by The Joint Commission with recognition by the National Committee for Quality Assurance (NCQA) as a Patient-Centered Medical Home. The 350,000 square foot educational building on the W.E. Upjohn M.D. Campus located in downtown Kalamazoo underwent a $78 million renovation and expansion project including two laboratory research floors and a state-of-the-art Simulation Center that is accredited by the Society for Simulation in Healthcare. The Innovation Center on the Parkview Campus is a life science, technology, and engineering incubator serving the earliest startups to maturing companies with laboratory, office and conference space, access to core scientific equipment and expertise, and a wide range of support services.

Kalamazoo is a wonderful and vibrant city, located midway between Chicago and Detroit. It is a short distance from Lake Michigan, and home to two nationally ranked institutions of higher learning, Western Michigan University and Kalamazoo College. Kalamazoo is known for its community focus and emphasis on access to quality education at all levels. The Kalamazoo Promise is a nationally renowned program in which graduates of Kalamazoo Public Schools receive free tuition to attend public and private colleges in Michigan. Kalamazoo and Michigan provide extensive entertainment and recreational activities, including opportunities to enjoy the outdoors, unique restaurants and shops, and a strong culture supporting the arts.

Western Michigan University Homer Stryker M.D. School of Medicine is an Equal Employment Opportunity/Affirmative Action employer of females, minorities, individuals with disabilities, and protected veterans, and actively strives to increase diversity within its community. We provide a drug- and tobacco-free workplace.

EEO Minorities/Women/Disabled/Protected Veterans.

Interested and qualified applicants should apply online at https://careers-wmich.icims.com/jobs/1385/post-doctoral-fellow-rothstein-lab/job and by sending his/her CV directly to Dr. Rothstein at tom.rothstein@med. wmich.edu. All other open positions are located on our main website at www.med.wmich.edu

Immunology, lymphocytes, B cells, antibody, immunoglobulin

Please apply via recruiter’s website.

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