Wellcome Trust Sanger Institute

Postdoctoral Fellow - Functional Genomics

Wellcome Sanger Institute

Cambridge, United Kingdom

We are looking to appoint a computational postdoctoral fellow in functional genomics to work with Emma Davenport and Gosia Trynka’s groups at the Wellcome Sanger Institute. This project is particularly suitable for a candidate with experience in analysing functional genomics datasets and the ambition to drive the analysis of a large single cell dataset.

Genome-wide associations studies (GWAS) have transformed our understanding of the genetic basis of autoimmunity, and have identified hundreds of genetic variants that confer disease susceptibility. However, the mechanisms by which most of these variants drive disease risk remain unclear, and the challenge of linking disease-associated variants to a causal mechanisms has limited the translational value of GWAS for drug development.

As part of an interdisciplinary team of experimentalists, clinical and industry collaborators you will lead an exciting project to map expression quantitative trait loci using large scale single cell RNA-seq data generated from 500 healthy and immune disease patients (sceQTLs). This is an excellent opportunity to be engaged in all aspects of a large-scale project, from planning and data generation through to analysis and novel discovery. Our goal is to accelerate drug discovery by integrating immune disease GWAS variants with the sceQTLs maps generated in this project to identify the most promising therapeutic targets for follow up by the industry partners working closely with us. This project forms part of the collaboration with Open Targets (https://www.opentargets.org/) and provides a great opportunity to deliver real translational solutions working at the Wellcome Sanger Institute, with industry partners including GSK, Celgene, Sanofi, Takeda and Biogen.

Essential Skills
• PhD in a relevant subject area (e.g. Bioinformatics, Biology, Genetics, Computational Biology, Statistics)
• Ability to communicate effectively with interdisciplinary team members and collaborators
• Ability to work both independently and as part of a team
• Ability to work with others in a friendly and collegiate environment
• Demonstrable high level of communication skills both written and oral
• A passion for problem solving and creative thinking
• Excellent organisational skills
• Experience in the analysis of functional genomic datasets (e.g. gene expression datasets)
• Proficiency in a scripting language (e.g. R, Python, Perl)
• Demonstrated ability to independently run data science projects

Ideal Skills
• Familiarity with the methods to generate functional genomics datasets
• Ability to develop novel statistical/computational methods

Other information
Open Targets is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Celgene, Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
• Group Defined Contribution Pension Scheme and Life Assurance
• Group Income Protection
• Private Health Insurance
• 25 days annual leave, increasing by one day a year to a maximum of 30
• Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
• Two days paid Employee Volunteering Leave a year
• Employee Discount Scheme
• Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
• Active Campus Sports and Social Club
• Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a CV and a cover letter describing your skills with your application.
Closing date: 08 December 2019

Please apply via recruiter’s website.