European Molecular Biology Laboratory (EMBL)

Postdoctoral fellow

European Molecular Biology Laboratory (EMBL)

Heidelberg, Germany

About the team/job

The Ries group at the Cell Biology and Biophysics Unit in Heidelberg is developing novel superresolution microscopy technologies to investigate the structure and dynamics of protein machines inside cells.
MINFLUX, a recent development from the Stefan Hell lab, is a superresolution method with the potential of achieving nanometer spatial and sub-second temporal resolution in living cells (Gwosch, Pape, Balzarotti, Hoess, Ellenberg, Ries, & Hell. MINFLUX nanoscopy delivers multicolor nanometer 3D-resolution in (living) cells. doi:10.1101/734251). This would allow us to directly image the dynamic functional changes of protein machines inside cells. At the EMBL we will receive one of the first commercial MINFLUX instruments, giving us unique access to this promising new technology. The aim of this project is to further develop and optimize MINFLUX to make it applicable to biological systems.

Your role

In close collaboration with the Abberior company and Stefan Hell’s group, the postdoc will:
• optimize optics, software, imaging modalities and sample preparation protocols;
• perform initial developments for a next-generation MINFLUX implementation for live biological samples;
• use MINFLUX to investigate the structure and dynamics of the nuclear pore complex and the endocytic machinery (in collaboration with biologists from the Ries and Ellenberg groups).

You have

Essential qualifications:
• a PhD in biophysics, physics or optical engineering;
• strong interest and prior experience with optics and programming and an interest in biological applications of new optical technologies.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, and the availability of an excellent child care facility on campus.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

Please apply online through:

Please apply via recruiter’s website.

Quote Reference: embl-HD01658