About the team/job
The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organizations in the world. The newest EMBL site is being established in the Barcelona Biomedical Research Park (PRBB), one of the largest infrastructures in Southern Europe dedicated to translational research.
The Ebisuya Group moved from RIKEN Japan to EMBL Barcelona in 2018. One of the research goals of the lab is to understand the molecular mechanisms by which larger species tend to show longer biological times. Why do human embryos develop more slowly than mouse embryos, for instance? Such a fundamental question remains unanswered partly because directly comparing human and mouse embryos is in many aspects difficult. Therefore, the lab utilizes in vitro differentiation of pluripotent stem cells (i.e., ES cells and iPS cells), recapitulating human and mouse developmental processes in the same culture condition. Taking advantage of the in vitro recapitulated systems, the lab quantitatively compares the speeds of developmental events and biochemical reactions between the species. For more information, read a recent preprint (Matsuda et al, bioRxiv, 650648, 2019).
You will systematically measure the biochemical reaction speeds, especially the degradation rates of proteins and mRNAs, of in vitro differentiated cells by using proteomics and/or RNAseq. The aim is to classify what genes show slower biochemical reactions in human cells as compared to the mouse counterparts and then identify the ultimate cause of the inter-species difference in the reaction speeds. You are expected to perform sample preparations, data analyses and follow-up experiments. This project will be part of international collaborations, and ample support will be provided by the current lab members and collaborators regarding both experiments and data analyses.
- PhD in bioinformatics, biochemistry, cell biology, molecular biology or related topic
Technical skills required:
- Experience in bioinformatics (analysing high-throughput data)
- Basic computer programming skills
- Basic wet lab experience in biochemistry, cell biology, molecular biology or related topic
- Fluent level of English
- Communication skills necessary for international collaborations
- Enthusiasm to tackle this big question in biology together with us!
You might also have
- Experience in an omics project (especially in next generation sequencing or mass spectrometry analysis)
- Experience in (stem) cell culture
- Basic knowledge of chemical reaction kinetics (e.g., how to calculate the degradation rate?)
Why join us
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family. EMBL Barcelona is established in the Barcelona Biomedical Research Park (PRBB), one of the largest infrastructures in Southern Europe dedicated to translational research, where researchers will benefit from a collaboration with other pioneering research institutes.
What else you need to know
We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1800 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.
Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.
Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.
This position will be supported by EMBL internal grant as well as PGC2018-097872-A-I00 (MCIU/AEI/FEDER, UE) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU) and co-funded by the European Regional Development Fund (ERDF, EU).