We are looking for an enthusiastic and highly motivated post-doctoral researcher to study cell competition in oesophageal and epidermal epithelia. Next-generation sequencing has revealed that somatic mutation to genes involved in cancer is surprisingly common in healthy adult tissues. Selected mutants form expanding clones that outcompete normal cells and can progress to form tumours. The successful applicant will utilise cutting-edge ex vivo primary cell culture techniques and CRISPR-Cas9 based gene editing and screening technologies to understand the basis of cell competition in normal tissues, and identify potential interventions to manipulate precancerous cell competition, with a view to developing new cancer prevention strategies.
Applicants should hold, or be close to completing, a PhD in a relevant subject, additional post-doctoral experience is desirable but not mandatory. The post is in the laboratory of Professor Phil Jones and will involve working closely with post-doctoral researchers and staff scientists in other teams at the Institute.
• A PhD in a relevant subject (e.g. cell and molecular biology, biochemistry, etc)
• Experience in cancer, cell or epithelial biology
• Publications in a relevant area
• Experience of planning complex research projects
• High level of trouble shooting skills
• Strong presentation and scientific writing skills
• Excellent time and project management skills
• Strong interpersonal and team working skills
• Excellent scientific record keeping
• Postdoctoral experience in a relevant discipline
• Computing experience (e.g. R, Python) sufficient to run bioinformatics packages
• Experience of CRISPR-Cas9 technology, analysis of next-generation sequencing data. flow cytometry, primary cell culture and/or genetic screens
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; we share our data, results, tools and technologies across the world to advance science. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog
Set across 130 acres, just outside of Cambridge, The Sanger Institute is located on the stunning Wellcome Genome Campus. Home to some of the world’s foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges.
There’s an attractive benefits package on offer at the Genome Wellcome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.
As well as the usual benefits you would expect, we go much further:
• 25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)
• Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)
• Up to 2 days annual paid volunteering leave
• Up to 10 days paid Emergency Carers Leave per year
• Family friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school children
• and Summer holiday club
• Life Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)
• Enhanced maternity leave and parental leave
• Access to substantial number of courses and training events onsite
• Private Healthcare Scheme (after 6 months service)
• Eyecare and Dental payment plans
• Concessions and discounts from our corporate perks site
Being part of the Genome Wellcome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:
• Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villages
• A car-share initiative
• Free parking
• A number of on-site venues where you can meet, eat and socialise with colleagues
• A thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of events
To find out more about our Genome Wellcome Campus, see here
We hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
Please include a covering letter and CV with your application. Closing date: 20 October 2019