Postdoctoral Fellow (Computational Genomics)
Salary: £31,897 to £39,986pa (dependent on experience) plus excellent benefits
Fixed-term: 3 years
Title: Prioritising therapeutic targets for 100 chromatin-related psychiatric and neurodevelopmental disorders
Now is an extremely exciting time for the study of human genomics. The Wellcome Sanger Institute (WSI) is a world leader in large-scale human genetics, model organism genetics, and computational genomics. We are consolidating and expanding an ambitious programme of research using the latest experimental technologies to characterise genetic variation and unravel the molecular basis of rare diseases and complex traits. This programme combines large-scale experimental data generation, on a variety of platforms, with sophisticated data analyses to identify causal variants underlying rare diseases and complex traits.
The successful applicant will join Matt Hurles’s group at the Sanger Institute, which includes experimental human and mouse geneticists as well as bioinformaticians and statistical geneticists. Our group focuses on identifying novel neurodevelopmental and psychiatric disorders, and on making and characterizing cellular (iPSC) and mouse models of those disorders.
The post-doctoral fellow will lead the large-scale computational analyses of RNA-seq datasets from cellular models for neurodevelopmental and psychiatric diseases. This role is part of a collaborative project between several academic groups funded by Open Targets (www.opentargets.org), a joint Sanger/EBI/Pharma initiative enabling disease relevant basic and translational research. In this project we are generating transcriptomic profiles from iPSC derived neural cells with CRISPR-engineered mutations modelling ~100 neurodevelopmental and psychiatric disorders due to mutations in chromatin-related genes, as well as transcriptomic profiles from drug response profiles of hundreds of pharmacological and genetic perturbations.
Applicants should have a background in Computational Biology or Computational Genomics, with either a proven track record in large-scale data analyses or who have demonstrated exceptional potential during a recently completed PhD. Strong data analytical skills are essential. Demonstrable experience of RNA-seq analysis is desirable. We are seeking a creative, highly-motivated and productive individual. Our work is collaborative and integrative. There will be opportunities to develop projects with other members of the group.
For further information, please contact Sebastian Gerety and Matt Hurles
Open Targets (www.opentargets.org) is an innovative, large-scale, multi-year, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation. Current members include Biogen, Celgene, EMBL-EBI, GSK, Sanofi, Takeda, and the Wellcome Sanger Institute.
• PhD in Computational Biology or a related discipline (e.g. Bioinformatics).
• Programming and bioinformatics skills
• Strong analytical skills
• Ability to work collaboratively with others in a friendly and collegiate environment.
• Effective communication skills within the team and with collaborators
• Efficient time management
• Able to work independently
• Knowledge of RNAseq QC, analysis, and interpretation.
• Strong demonstrable experience in RNAseq QC, analysis, and interpretation
• Previous publications in the areas of pathway analysis, and large dataset integration.
• Demonstrable experience of statistical analysis of genomic or transcriptomic data
• An interest in genetic disorders, and in finding ways to identify therapeutic targets
• A passion for problem solving and creative thinking.
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; we share our data, results, tools and technologies across the world to advance science. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog
Set across 130 acres, just outside of Cambridge, The Sanger Institute is located on the stunning Wellcome Genome Campus. Home to some of the world’s foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges.
There’s an attractive benefits package on offer at the Genome Wellcome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.
As well as the usual benefits you would expect, we go much further:
• 25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)
• Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)
• Up to 2 days annual paid volunteering leave
• Up to 10 days paid Emergency Carers Leave per year
• Family friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school children
• and Summer holiday club
• Life Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)
• Enhanced maternity leave and parental leave
• Access to substantial number of courses and training events onsite
• Private Healthcare Scheme (after 6 months service)
• Eyecare and Dental payment plans
• Concessions and discounts from our corporate perks site
Being part of the Genome Wellcome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:
• Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villages
• A car-share initiative
• Free parking
• A number of on-site venues where you can meet, eat and socialise with colleagues
• A thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of events
To find out more about our Genome Wellcome Campus, see here.
We hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
Please include a covering letter and CV with your application.
Closing date for applications: 29th August 2019