Children's Research Institute (CRI), Children's National Health System

Postdoctoral Fellow

Children's National Hospital

Washington, DC, United States

Postdoc positions are available in the laboratory of Wei Li at Children’s National Hospital, Washington, DC. In the past we have developed innovative bioinformatics algorithms to design, analyze and visualize genome-wide CRISPR/Cas9 knockout screening data, used CRISPR screening to identify genes responsible for drug resistance and synthetic lethality, and further understand the functions of non-coding elements. We are devoted to using cutting-edge computational methods, in combination with new genome engineering and single cell approaches to understand how coding and non-coding elements function in cancer and childhood diseases.

The successful applicant will be responsible for (1) establishing the basic components of a molecular biology and genomics lab, (2) utilizing CRISPR-Cas9 based gene editing and single cell technologies to understand human cancer and rare disease, and (3) identifying potential interventions. Candidate will also have the opportunity to receive rigorous training in bioinformatics and computational biology, and be under the joint supervision of collaboration labs at Children’s National. Prior lab experience with molecular biology techniques (e.g., CRISPR/Cas9) is required.

Ideal applicants are expected to:

  • Hold Ph.D. degree in cellular and molecular biology, biochemistry, etc.
  • Be experienced in molecular biology (tissue culture, PCR, cloning, genotyping, RNA and DNA isolation, flow cytometry, Western blots, etc.)
  • Familiar with genome editing (CRISPR/Cas9)
  • Demonstrate independent critical thinking and rigorous work.
  • Have strong record of productivity and good publication record in peer-reviewed journals.
  • Have strong personal skills, and excellent verbal and written communication skills.
  • Work effectively both independently and collaboratively
  • Prior knowledge of pediatric diseases not required.

Candidates will join the outstanding research community at Children’s National Hospital and George Washington University, and have the opportunity to interact with scientists at nearby institutions including National Institute of Health (NIH), John Hopkins University, University of Maryland, etc.

Children’s National Hospital, based in Washington, D.C., has been serving the nation’s children since 1870. Children’s National is #5 overall, #1 for babies and ranked in every specialty evaluated by U.S. News & World Report for children’s hospital in the U.S. Home to the Children’s Research Institute, Children’s National is one of the nation’s top NIH-funded pediatric institutions. Children’s National is recognized for its expertise and innovation in pediatric care and as a strong voice for children through advocacy at the local, regional and national levels.

As the capital of United States, Washington DC is the hub of American politics and history. Washington DC metropolitan area (including Virginia and Maryland) is the home of people from diverse backgrounds, and is considered one of the best places to live and work in US.

By joining a newly established lab, the candidate will have unique opportunities to set up a research laboratory and interact with the PI/collaborators. The candidate will also gain experiences and guidances in a variety of aspects including grant writing, presentation, career transition, networking, etc.


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Postdoctoral Fellow