Postdoctoral Fellow

Brigham and Women's Hospital (BWH), United States

Boston, MA, United States

Postdoctoral Fellowship

Platelet-based therapies for Malignacy

Harvard Medical School

Brigham and Women’s Hospital

 

 

NIH funded postdoctoral position is available in the laboratory of Dr. Elisabeth Battinelli of Harvard Medical School/Brigham and Women’s Hospital in the Brigham Platelet Group (http://bwhplateletgroup.bwh.harvard.edu) (Multi-PI Group including Dr. Joseph Italiano) on role of platelets in the tumor microenvironment.

 

We are interested in how platelets support metastatic spread and how we can utilize anti-platelet agents to disrupt the crosstalk between platelets and tumor cells. Our laboratory was the first to demonstrate that platelets differentially store and release the neovascular and pro-malignant cytokines stored in their alpha granules in response to tumor cells (Italiano et al 2008 and Battinelli et al 2008). We have also demonstrated that anti-platelet agents can be used to regulate the role of platelets in malignancy; thereby establishing a new therapeutic modality for malignancy (Kuznetsov et al, 2012; Battinelli et al, 2014; Machlus et al, 2016; Johnson et al 2017; Johnson et al, 2019). We have also demonstrated a role of platelets in non-solid tumor malignancy including multiple myeloma (Takagi et a., 2018). Our main focus is to harness the power of platelets to develop therapeutic targets to decrease metastatic diseases: 1) Understand the molecular crosstalk between platelets and tumor cells; 2) Identify new platelet targets for regulating platelet and tumor cell interactions; 3) Understand the role of anti-platelet agents such as aspirin in decreasing tumor metastatic growth; 4) Understanding the role of malignancy on Megakaryocytes, the mother cell of platelets; 5) Develop novel anti-neoplastic therapeutic agents that target the platelet and tumor cell interaction.

 

The positions offer unique and exciting opportunities to engaging in developing cross-disciplinary work from basic understanding to translational application to improve malignancy outcomes. The project involves collaboration with Dr. Joseph Italiano of Brigham and Women’s Hospital as well as physicians at Dana Farber Cancer Institute. We provide an interdisciplinary and collaborative environment in all aspects of research to understand the roles of the platelet in the tumor microenvironment from animal model to patients. A successful candidate (Ph.D., M.D./Ph.D. or M.D.) should have a background in cancer biology and hematology and strong interest in developing novel platelet based therapies for malignancy.

 

Please email a curriculum vita, a description of research accomplishments and names of three references to:

 

Elisabeth M. Battinelli M.D./Ph.D.            

Assistant Professor                                                

Harvard Medical School                                        

Brigham and Women’s Hospital   

embattinelli@bwh.harvard.edu

 

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Position

Postdoctoral Fellow