Umeå University (UmU)

Postdoctoral Fellow: Autophagy and Chemo-optogenetics

Department of Chemistry, Umeå University (UmU), Sweden

Umeå, Sweden

Umeå University is dedicated to providing creative environments for learning and work. More than 4300 employees and 33979 students from over 60 nationalities have already chosen Umeå University. The recent breakthrough researches from Umeå include deciphering the molecular mechanisms of the bacterial CRISPR-Cas9 system and repurposing it into a tool for genome editing, a method developed at Umeå university that was awarded Nobel Prize in Chemistry 2020.

The Wu lab recently relocated from Max Planck Institute (https://www.mpi-dortmund.mpg.de/en) in Dortmund Germany to Umeå Sweden. The lab is located within the cross-disciplinary Chemical Biological Centre (www.umu.se/en/kbc/; video: https://vimeo.com/88655847) at Umeå University and is affiliated with Umeå Centre for Microbial Research, a Centre of Excellence Sweden (http://www.ucmr.umu.se/). The lab is fully equipped for biological and chemical researches with access to excellent facilities and state-of-art equipment and platforms in a creative, inspiring, international and highly interactive environment. Facilities include Protein Expertise Platform, X-ray, proteomics, NMR (850-400 MHz), cryo-EM and Biochemical Imaging Centre (confocal, FLIM, spinning disk, TIRF, STORM).

Project 1: Autophagy

Autophagy is an evolutionarily conserved self-eating process mainly to eliminate or recycle dysfunctional cellular organelles or proteins. Autophagy plays an important role in physiology including development and ageing and has been associated with diverse human diseases, including cancer, neurodegeneration and pathogen infection. Despite extensive work, the mechanisms of autophagosome formation and autophagy regulation are not yet well established. Our laboratory has elucidated fundamental mechanisms underlying autophagosome formation and bacterial interaction with host autophagy (eLife 2017, Angew Chem 2017, Nat Chem Biol 2019, JCS 2020). We will combine cell biological, biochemical, and novel chemical and chemo-optogenetic approaches to understand the mechanism of autophagic membrane morphogenesis.

For information about project details, qualifications and how to apply for the postdoctoral fellowship of the autophagy project, please see the advertisement at our website:

https://www.umu.se/en/work-with-us/postdoctoral-scholarships/6-2319-20/ Mark your application with the reference number FS 2.1.6-2319-20.

Project 2: Chemo-optogenetics

Chemical/light-inducible approaches provide means to control biological systems with spatial and temporal resolution that is unmatched by traditional genetic perturbations. However, canonical optogenetic systems using photoreceptors suffer from inherent limitations in basal activity in the dark, dynamic range and maneuverability. Our laboratory has pioneered in the development of chemo-optogenetic systems (Chemistry 2019 review), including a set of chemical and photochemically induced dimerization (CID, pCID, psCID) systems to spatiotemporally control cellular signaling and intracellular cargo transport (Angew Chem 2014, 2017, 2018s). We will develop novel chemo-optogenetic systems that enables the activity to be controlled by light with high spatial and temporal precision in live cells and organisms.

The project is interdisciplinary with strong international collaborations across scientific disciplines. The European Research Council (ERC) and Wallenberg Foundation are funding the research in long term.

For information about project details, qualifications and how to apply for the postdoctoral fellowship of the chemo-optogenetics project, please see the advertisement at our website:

https://www.umu.se/en/work-with-us/postdoctoral-scholarships/6-2320-20/ Mark your application with the reference number FS 2.1.6-2320-20.

For further information you are welcome to contact Prof. Yaowen Wu E-mail: yaowen.wu@umu.se. Website: https://www.umu.se/en/staff/yaowen-wu/

https://www.biostruct.umu.se/principal-investigators/yaowen-wu/

About the department

The Department of Chemistry is one of the largest departments within the Faculty of Science and Technology with approximately 200 employees, of which approximately 40 PhD students, and a strong and expanding research. The Department has three major research areas: Biological Chemistry, Environmental and Biogeochemistry, and Technical Chemistry. http://www.chemistry.umu.se/english/

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Position

Postdoctoral Fellow: Autophagy and Chemo-optogenetics