Post-doctoral Fellow / Assistant Staff Scientist
Posting Number: 000113
Position Type: Scientific
Department: Arthritis & Clinical Immunology – Nath
Job Summary/Basic Function:
The Nath Lab is seeking a highly motivated, hardworking and organized team player (Post-doctoral Fellow / Assistant Staff Scientist) to join our effort to understand genetic mechanisms of lupus, an autoimmune disease. Using whole genome search, our lab has identified several genes/genetic variants, associated with lupus susceptibility. Now we are trying to understand the specific functional effects of those lupus associated genetic variants, using cell lines, patients-derived primary immune cells or tissues. We will apply various modern techniques for studying features of three-dimensional (3D) genomic organization such as 3C, Hi-C, ChIP-Seq, and genome editing using CRISPR/Cas9. Candidate will be involved in the analysis of human genetic data and the development of computational methods, which requires a mix of computational skills, statistical knowledge, creativity and biological insight. Specifically, candidate will identify novel therapeutic targets and biomarkers from the investigation of human genetic variation (GWAS, Next Gen Sequencing) with disease status and intermediate variables using cutting-edge techniques in Statistical Genetics. Candidate will develop and apply methods for the integration of GWAS summary results with other types of data e.g. eQTL, mQTL, functional genomic annotations, gene networks, estimation/partitioning of heritability, Mendelian Randomization to understand causal direction, and fine mapping. Candidate will collaborate with experimental and clinical scientists to address target mechanism specific questions and seek to support investment decision making with genomic insights.
Ph.D. in a biological science or other relevant area, M.D., or equivalent.
A candidate should have a doctoral degree in epidemiology, biostatistics, genetics, bioinformatics, statistics, computer science or related fields. Knowledge of statistical genetic methods for gene-mapping for complex traits, and computer programming skills (e.g. familiarity with UNIX-like OS, and at least one programming language) are required.
Minimum Degree Required:
The successful applicant is expected to have a strong interest in genetic epidemiology of complex traits and will have experience in both the application/implementation of established methods for genetic linkage and association studies, and in methods development. Experience in genomics, cloning and functional characterization of genes will get preference.
Regularly required to stand, use manual dexterity, talk or hear; Frequently required to walk and reach with hands and arms; occasionally sit; frequently lift and/or move up to 50 pounds; vision abilities include close vision, color vision, depth perception and ability to adjust focus. Potential exposure to fumes, airborne particles, or rodent dander. May work with toxic, caustic chemicals, radioactive materials, liquid nitrogen, human tissue or blood. Potential risk of electrical shock. Occasional exposure to cold 4C, and/or extreme cold -80C from freezers. Noise level is usually moderate.
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