The laboratory of Dr. Vaibhav Patel at the Libin Cardiovascular Institute of Alberta and Department of Physiology and Pharmacology invites applications for a postdoctoral fellow (Starting immediately) and a graduate student (Starting in January/May/September 2020) to support our projects focused on identification of molecular mechanisms of various Cardiovascular Disease.
The postdoctoral scholar must be a highly qualified and motivated individual with a strong background in murine models of heart failure and vascular diseases. The graduate student must be enthusiastic, hard-working, and committed individual and must meet minimum admission requirements pertaining to GPA and language proficiency prior to applying. Competitive stipends will be provided, and top-ups will be made available for trainees acquiring extramural scholarships/fellowships.
Both candidates will work on research projects investigating the roles of exosomes in intercellular communications and their impact on cardiovascular disease. Experimental approaches and tools will include transgenic mice, human specimens, cardiomyocytes, fibroblasts and progenitor cell isolations, next-generation sequencing/bioinformatics, cardiovascular phenotyping, and cellular & molecular biology. The postdoctoral scholar will also have access to state-of-the-art core centers to perform cutting edge research. Salary will be commensurate with experience.
Graduate Study applicant must have an excellent English language proficiency and academic track record, experience in preclinical and molecular biology laboratory techniques, background and interest in cardiovascular sciences.
The postdoctoral applicant must have completed Ph.D. in Biomedical Sciences or other related disciplines within last two years with impressive publication record to be competitive for provincial and national scholarships. Extensive experience of working with human and murine primary cells, basic and advanced molecular biology experiments, including but not limited to, Western blotting, immunostainings, confocal microscopy, flow cytometry are required. Candidate must have a strong interest in cardiovascular sciences, strong academic record, and fluency in English (oral as well as written).
Duties and Responsibilities include:
· Perform physiological experiments in mice (i.e., evaluation of cardiac function using Millar PV loops system (e.g., LVSP, RVSP, dP/dt, EF). Analysis and interpretation of murine echocardiography data including cardiac function and coronary flow reserve. Murine models of myocardial infarction, cardiac ischemia/reperfusion, dissection of heart and small arteries.
· Isolation of cardiomyocytes, cardiac fibroblasts and endothelial cells.
· Conduct basic molecular biological experiments (e.g., Western Blot, PCR, qPCR, Flow Cytometry, immunostaining and confocal microscopy).
· Data acquisition, analysis, manuscript preparation, and presentation of findings at weekly lab meetings and national/international meetings.
· Maintaining the function of various lab equipment, managing the lab research record (including methodological approaches and animal protocols), training graduate students for various experimental techniques and maintaining transgenic mouse colony.
Individuals interested in applying for this position should submit a curriculum vitae, a cover letter including a statement of research interests and goals, relevant publications and GPA (only for graduate study applicant) and the names of three references to the address below (email is preferred). Applications will be accepted on an ongoing basis until the position is filled. Only those applicants selected for interviews will be contacted.
Vaibhav Patel, M.Pharm., Ph.D.
Department of Physiology & Pharmacology,
Cumming School of Medicine, University of Calgary
3330 Hospital Drive NW
Calgary, AB, T2N 4N1
To learn more about postdoctoral scholar opportunities at the University of Calgary and all we have to offer, view our Postdoc Careers website. For more information about the Cumming School of Medicine visit Careers in the Cumming School of Medicine.
About the University of Calgary
The University of Calgary is a leading Canadian university located in the nation’s most enterprising city. The university has a clear strategic direction to become one of Canada’s top five research universities by 2016, where innovative teaching and groundbreaking research go hand in hand, and where we fully engage the communities we both serve and lead. The strategy is called Eyes High, inspired by our Gaelic motto, which translates to ‘I will lift up my eyes.’
To succeed as one of Canada’s top universities, where new ideas are created, tested and applied through first-class teaching and research, the University of Calgary needs more of the best minds in our classrooms and labs. We’re increasing our scholarly capacity by investing in people who want to change the world, bringing the best and brightest to Calgary to form a global intellectual hub and achieve advances that matter to everyone.
About Calgary, Alberta
Named a cultural capital of Canada and one of the best places to live in the world, Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city. Calgary is less than an hour’s drive from the Rocky Mountains and boasts the most extensive urban pathway and bikeway network in North America.
The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.