This appointment is to work within the laboratory of Professor Sundrud and will focus on the local regulation of mucosal T cell function by bile acids in the small intestine. The Sundrud lab has recently demonstrated that circulating T cells sense and respond to the presence of locally-reabsorbed bile acids in the ileum to maintain homeostasis and suppress the development of small bowel inflammatory disease (PMID: 29262351); the lab has new R01-level funding to explore the T cell-intrinsic functions of ligand-operated nuclear receptors in T cell-bile acid cross-talk in the intestine.
The successful candidate will contribute to all aspects of the project, including both in vitro and in vivo T cell analyses, molecular cloning, retroviral T cell transduction experiments, as well as execution and analysis of high-content flow cytometry, RNA-seq, DNA-seq and ATAC-seq experiments.
The successful candidate will work in a fast-paced and dynamic group environment and will be supported by a full-time Senior Research Assistant.
- To learn more about this position, please visit Sundrud lab: www.sundrudlab.com. In order to be considered for a position, you must apply through the job posting: Requisition 06557.
Experience with cloning, T cell culture, animal models of autoimmune and chronic inflammation, and next-generation sequencing is required. The successful candidate must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Expertise in molecular cloning, CRISPR/Cas9 gene editing, shRNAmir-mediated gene knockdown and animal models of inflammatory bowel disease is preferred.
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- The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.