Howard Hughes Medical Institute (HHMI)

Postdoctoral Associate - Glia-Neuron Interaction

Howard Hughes Medical Institute (HHMI)

Ashburn, United States

The O’Shea Lab at the Janelia Research Campus of HHMI is looking for a Postdoctoral Associate to join our group that is investigating interactions between glia and neurons. 


We use cell culture, biochemistry, microscopy, and rodent in vivo models to understand how glia interact with neurons in normal physiology and disease. We are interested in the basic cell biology of glia, and also in the mechanistic basis underlying synaptic pruning, the process by which synapses are selectively removed from the brain. There are many possible projects in the general area of glia-neuron interactions, including:

  • The role of astrocytes in synaptic pruning
  • The mechanisms by which microglia and astrocytes select synapses to be pruned
  • The determinants that limit synapse pruning to specific developmental times
  • The role of MHC molecules in synapse pruning
  • The physiological signals that promote changes in microglial morphology and phagocytic capacity



  • PhD in a relevant field
  • Experience working with glia and neurons is highly desirable
  • Experience in some of these areas: cell culture, biochemistry, microscopy, work with rodents


To learn more about the O’Shea lab, please visit


HHMI is an equal opportunity employer.

Please apply via recruiter’s website.

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