Université Libre de Bruxelles (ULB)

Postdoctoral and Technician positions in RNA biology, Ribosome Biogenesis, Nucleolus, University of Brussels, Belgium

Denis L.J. LAFONTAINE

Gosselies, Belgium

Post-Doctoral fellowships and a Technician position are available to join the Lafontaine Lab (Www.LafontaineLab.com) at the University of Brussels, Belgium to study ribosome biogenesis and the structure/function relationships in the nucleolus in human cells and animal models.


We are interested to learn how ribosome biogenesis dysfunction may ultimately lead to human diseases. There are ribosomes in every cells, nonetheless the reduced production of functional ribosomes only impacts specific tissues (blood, brain). We are also studying the nucleolus, a biomolecular condensate formed by liquid-liquid phase separation. We have recently learned that it’s possible to modulate ribosome biogenesis by altering the material properties of the nucleolus.


Our activities are described here Www.LafontaineLab.com


Postdocs: the contracts are for two years initially

Eligibility:

• Your PhD was delivered less than six years ago

• You have not resided or carried out your main research activity in Belgium for more than 24 months during the last 3 years


Profile #1:

- Molecular biology & RNA biochemistry

- Preparation of deep sequencing libraries

- Analysis of deep sequencing data


Profile #2:

- High-end fluorescent microscopy: confocal, live-cell imaging, FRAP, super resolution

- Image processing analysis (Image J, MatLab)

- CRISPR-Cas9 genome editing

- Experience with electron microscopy (sample preparation and imaging) is an advantage


Technician: the contract is for one year initially

- Tissue section preparation on frozen and embedded material (biopsies)

- Immunohistochemistry (IHC) and immunofluorescence

- Fluorescence microscopy

- A capacity to use image processing softwares is an advantage


Where?

-The Biopark campus (http://www.biopark.be/en) offers an attractive international research and study environment with approximately 600 scientists active in key areas of molecular life sciences and medicine. It is located ~50 km south of Brussels, next to the Charleroi International Airport (www.charleroi-airport.com/en/index.html).


-The campus hosts the Center for Microscopy and Molecular Imaging (www.cmmi.be) with a suite of state-of-the art microscopes (high-throughput screening, confocal, FRAP, super resolution, CryoEM)

 

How to Apply?

• Applications will be accepted immediately and candidates will be considered until the positions are filled.

• To be considered, all applicants must submit a short cover letter (explain briefly why you think you are a potential fit), a curriculum vitae including a complete list of publications, and the names and contact details of three references.

• A single PDF document should be sent to Prof Denis Lafontaine (denis.lafontaine@ulb.ac.be).

• The contracts may start as soon as 1st of February 2020.


Key Publications

Lafontaine, DLJ (2019) Molecular Cell

Zhu et al (2019) PNAS USA

Van Tran et al (2019) NAR

Stamatopoulou et al (2019) Nature Protocols

Vendramin et al (2019) Nature Struct Mol Biol

Marchand et al (2019) Angew Chem Int

Nicolas et al (2016) Nature Comms

Leucci et al (2016) Nature

Sharma and Lafontaine (2015) TiBS

Lafontaine (2015) Nature Struct Mol Biol

Létoquart et al (2014) PNAS USA

Tafforeau et al (2013) Molecular Cell

 

 

 


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Position

Postdoctoral and Technician positions in RNA biology, Ribosome Biogenesis, Nucleolus, University of Brussels, Belgium