Novo Nordisk Research Centre Oxford (NNRCO)

Postdocs in Functional Genomics for Type 2 Diabetes and Cardiometabolic Disease

Novo Nordisk Research Centre Oxford

Oxford, United Kingdom

Join Novo Nordisk Research Centre Oxford (NNRCO) as our new Postdoc and become a part of a newly established Translational Research Unit. As our new Postdoc, you will join the Department of Discovery Biology and Pharmacology focusing on Functional Genomics.

About the department
NNRCO is our new Translational Research Unit (TRU) focused on biology and target discovery across the broad spectrum of cardiometabolic disease. We aim to combine the very best of academia, biotech and big pharma, fusing deep understanding of disease biology, an agile creative culture and drug development. NNRCO will be a world-leading research site focused on asking the big and difficult questions and delivering high impact science. We will use genetics, functional genomics, human-centric disease models and computational biology to develop an unparalleled understanding of cardiometabolic disease and deliver therapies that transform the lives of patients.

Our location in the heart of the University of Oxford medical campus enables two-way collaborations with some of the best medical scientists in the world. These collaborations will include strategic investments in areas of mutual interest as well as jointly supervised PhD students and postdocs.

Our agile creative culture allows our scientists a high degree of individual autonomy to drive their own projects building on deep internal and external collaborations. Furthermore, cross-country collaborations within the organisation are part of our normal working environment and NNRCO scientists are an integral part of the Novo Nordisk Global Drug Discovery unit, which specialises in discovery and development of biological medicines.

You can read more about Novo Nordisk Research Centre Oxford at: http://www.novonordisk.co.uk/about-novo-nordisk-in-uk/oxford-research-centre.html

The Department of Discovery Biology and Pharmacology is led by Sr. Head of Dep., Nicola Beer PhD, and consists of Specialists, Staff Scientists, and Postdocs. The focus of this Department is to generate and use human-centric cellular models (including stem cells) to enable phenotypic and discovery screens aimed at uncovering novel biology relevant to type 2 diabetes and cardiometabolic disease. The Department also takes these data through to proof-of-concept studies within humanised in vivo model systems.

The position
We are looking for highly motivated Postdoctoral Scientists in Functional Genomics with a passion to work on state-of-the-art projects in human genetic-driven drug discovery for Type 2 Diabetes and cardiometabolic disease. In this position you will drive the functional validation of targets with novel modes of action, as identified primarily by human genetic and genomic data. You will use a combination of genome engineering/editing and stem cells to achieve this goal, alongside setting up disease-relevant cellular phenotyping assays to test hypotheses and uncover causal mechanisms. You will also work alongside both computational and laboratory biologists, statistical geneticists, and with external collaborators to discover and validate new biology and therapeutic targets.

Crucially, this work will support NNRCO’s delivery of discovery screens, alongside more bespoke biology-driven cellular projects. We welcome candidates with a good team ethic and great attention to detail. This role also suits candidates who enjoy a fast paced, dynamic environment where creative intellectual independence is actively encouraged. Applicants are asked to clearly indicate, in a cover letter, their motivation to work with human cells and genome engineering technologies in the early stages of the drug discovery process.

We are looking for two full-time Post-docs for a 36-month period.

Qualifications
You have a PhD in a relevant scientific field and some years of experience in a relevant laboratory setting including genome engineering and stem cell biology. Ideal candidates will have experience in genome engineering, particularly using and manipulating mammalian cell models to generate human genetic and genomic data, alongside other bioassays and cellular phenotyping. Experience in diabetes, metabolism, and cardiometabolic disease is highly desirable.

You will be expected to work well both independently designing and driving the direction of projects, as well as collaboratively as part of a team alongside other inter-disciplinary colleagues in the project team and across NNRCO departments.

We expect you to be flexible, open to new ideas, and result oriented. The job requires proficiency in English and excellent communication and collaboration skills.

Working at Novo Nordisk
At Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global work place, where passion and engagement are met with opportunities for professional and personal development.

Please apply via recruiter’s website.

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