Are you looking for an interesting postdoc position in cell and chemical biology? We are looking for a postdoc to work on a project aimed at chemical biological approaches to redirect TGF- signaling.
Transforming growth factor- (TGF-) is of key importance in development and maintenance of tissue homeostasis. Work in the Ten Dijke lab is focused on the understanding how TGF-β signaling is perturbed in cancer, and to find new ways to target this pathway for therapeutic gain. In this role you focus on the development of synthetic bioactive molecules that selectively modulate protein-protein interactions or enzymatic activities involved in TGF- signaling. Examples of such molecules include nanobodies, macrocyclic kinase inhibitors, PROTACs (Proteolysis targeting chimeric molecules) and modulators of the ubiquitin machinery.
As a team we take a multidisciplinary approach, including high-throughput chemical screens, genetics, (bio)chemistry, cell biology, zebrafish/mouse models and mathematics and bioinformatics.
Working at the LUMC
The LUMC is a center for medical innovation that aims to improve patient care through leading international research. So as to also provide our patients with a safe and friendly environment, we need doctors, medical care specialists, support staff and academic researchers.
The Department Cell and Chemical Biology is equipped with state-of-art facilities for molecular and cell biology, microscopy, chemistry, proteomics, genetics (including DNA editing) and protein chemistry. We believe that curiosity-driven experimental research by talented researchers is at the very heart of true progress in biomedicine.
You are a highly motivated candidate who:
- has recently obtained a PhD degree in chemical or molecular cell biology;
- has expertise in biochemistry and multiple years of experience;
- has proven research abilities and an excellent publication record;
- can work both independently and in a team.
You will be employed on the basis of a 36-hour week. Appointment is for two years, with a possible extension. The salary will depend on your qualifications and experience, with a maximum of € 4,361 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).
A detailed description of this position can be found on www.werkenbijhetlumc.nl. If you have any questions or would like more information about this position, please contact Peter ten Dijke, professor and section head, Department of Cell and Chemical Biology, telephone +31(0)71 526 92 71.
How to apply
If you are interested in this position, please complete the application form by the 2nd of June 2019 at the latest.
Please include a motivation letter and a CV with two references with your application.
You may also apply through the website www.werkenbijlumc.nl.
Link to application form (to be completed by LUMC): https://bit.ly/2w3EXTQ