Leiden University Medical Center (LUMC)

Postdoc SUMO & the Ubiquitin-proteasome System

Leiden University Medical Center (LUMC)

Leiden, Netherlands

In short
job vacancy number : D.19.MH.CV.09
closing date for application : December 1st 2019

The position
Would you like to be a postdoc on a TOP-project to study the role of SUMOylation in protein degradation? The LUMC offers a challenging research position in an exciting, international environment. Read on!

Our group is interested in the mechanisms and functional consequences of post-translational protein modification by SUMO and ubiquitin. We integrate biochemistry, cell biology and proteomics approaches and use state-of-the art microscopes and mass spectrometers to obtain novel insights in SUMO and ubiquitin signal transduction. We have previously shown that SUMO-2/3 are able to form chains in an ubiquitin-like manner. These chains then cooperate with the ubiquitin-proteasome system to regulate target protein degradation. Furthermore, we have recently developed innovative methodology to study SUMOylation and crosstalk between SUMOylation and ubiquitin in a cell-wide manner. You will investigate crosstalk mechanisms between post-translational protein modification by ubiquitin and SUMO (Small Ubiquitin-like Modifier) in cooperation with the group of Prof. Dr. Huib Ovaa in our department. You will study the important roles of SUMO and ubiquitin in protein degradation at a proteome-wide level and at the level of individual target proteins.

The profile
You are an enthusiastic, flexible colleague who:

  • has obtained a PhD degree in biomedical sciences or a similar field
  • has a strong background in protein purification, protein biochemistry, molecular biology and cell biology
  • preferably has experience with ubiquitin-like proteins and protein degradation
  • is creative, skilled and results driven
  • possesses solid communication skills, both orally as in writing.

The offer
You will be employed on the basis of a 36-hour week. Appointment is for a maximum of three years. The salary will depend on your qualifications and experience, with a maximum of € 4,481 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).

Working at LUMC
The LUMC is a center for medical innovation that aims to improve patient care through leading international research. So as to also provide our patients with a safe and friendly environment, we need doctors, medical care specialists, support staff and academic researchers.
Within the Department of Cell and Chemical Biology, a team of professionals investigates functional regulation of proteins by post-translational modifications including SUMOylation, ubiquitylation and phosphorylation. This enables us to improve our knowledge about fundamental processes of life at the molecular level and to improve our knowledge about disease-linked de-regulation of these processes.

More information
A detailed description of this position can be found on www.lumc.nl (select ’Working at the LUMC’). If you have any questions or would like more information about this position, please contact Prof. Dr. Alfred Vertegaal, Department of Cell and Chemical Biology. Telephone: +31 (0)71 526 96 21, e-mail: vertegaal@lumc.nl.

References can be requested as part of the procedure. You might be asked to give a presentation.

How to apply
If you are interested in this position, please complete the application form by December 1st, 2019 at the latest. You can also apply through the website www.lumc.nl/vacatures.

Please apply via recruiter’s website.