We are recruiting postdoc scholars who love science and dare to invent
We welcome bold minds who will innovate in RNA biology and technologies, including spatial, single-cell, and extracellular transcriptomics. We are interested in revealing novel RNA types and functions. Our favorite application areas include blood vasculature in diverse tissues and diseases, liquid biopsy-based diagnoses, and mechanisms of Alzheimer’s disease and metabolic diseases. Ph.D.s in RNA biology, bioinformatics, molecular biology, or nucleic acid biochemistry are most welcome.
About the PI
Sheng Zhong is a Professor of Bioengineering at UC San Diego. He received an NIH Director’s Pioneer Award, an NIH Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases, an NIH Director’s New Innovator Award, an NSF CAREER Award, and an Alfred Sloan Fellowship. He serves as the director for the organizational hub of the NIH funded 4D Nucleome (4DN) Network. He leads a Human Cell Atlas (HCA) seed network and a Transformative Technology Development team for the Human BioMolecular Atlas Program (HuBMAP). Eight of his former associates are contributing to science on tenure-track faculty positions.
About the lab
Our lab invented the MARIO (Mapping RNA interactome in vivo) technology to massively reveal RNA-RNA interactions from human tissue (Nat Comm, 2016). We also invented the MARGI (Mapping RNA-Genome Interactions) technology for revealing thousands of chromatin-associated RNAs (caRNA) and their respective genomic interaction sites (Current Biology, 2017; Nature Protocols, 2019). Leveraging MARGI, we and our collaborators characterized caRNA’s roles in 3D organization of the nucleus (iScience 2018a), modulation of gene expression during progression of diabetes mellitus in blood vessel endothelium (Nat Comm, 2020), and the biogenesis of fusion RNAs (PNAS 2019a).
We contributed to discovering that the earliest cell fate decision in mice is made sooner than the commonly thought 8-cell stage (Genome Res, 2014). Our Rainbow-seq technology combined tracing of cell division history and single-cell RNA sequencing into one experiment (iScience 2018b).
We developed SILVER-seq for extracellular RNA (exRNA) sequencing from ultra-small volumes of liquid biopsy, solidifying a basis for future in vitro diagnostic trials using finger-prick blood for breast cancer (PNAS, 2019b) and Alzheimer’s disease (Current Biology, 2020).
We contributed to revealing that transposons are indispensable regulatory sequences in the mammalian genomes. Species-specific transposons are required for preimplantation embryonic development in humans and other mammals (Genome Res, 2010). Nature highlighted this discovery as ‘Hidden Differences’, reporting that “transposons or ‘jumping genes’ had hopped in front of the genes, changing their regulation” (Nature, 2010). We contributed to establishing the proof-of-principle that cis-regulatory sequences can be annotated by cross-species epigenomic comparison (Cell, 2012).
Visit us at http://systemsbio.ucsd.edu. UCSD is an equal opportunity employer with a strong institutional commitment to excellence through diversity. We look forward to learning your expertise and interests.