Flanders Institute for Biotechnology (VIB)

Postdoc position: Molecular connectomics of neural circuits

Flanders Institute for Biotechnology (VIB)

Leuven, Belgium

About the lab

The De Wit lab (Laboratory of Synapse Biology) at the VIB-KU Leuven Center for Brain & Disease Research, Belgium, is seeking a highly motivated postdoctoral fellow to work on a project on molecular connectomics of neural circuits.

About the project

Neural circuits are composed of different neuronal cell types connected in highly specific patterns. Single-cell sequencing has provided a major advance in dissecting brain cell type diversity at the molecular level. However, it is the projections between these cells and their specific properties that make a neural circuit. Understanding the brain therefore requires approaches to dissect its connectome at the molecular level. This project aims to optimize and develop new approaches to dissect and map the molecular synaptic connectome that controls connectivity and function of neural circuits.

Your job

The main goal of our laboratory is to unravel the molecular mechanisms that control precise synaptic connectivity in developing circuits and determine how perturbations in this process affect circuit function (see references below). In this project, you will make use of innovative proteomics approaches, genome engineering, viral vector technology and state-of-the-art imaging to characterize the molecular composition of specific projections in mouse hippocampal and cortical circuits.

Selected references:

  • Apóstolo et al. BioRxiv https://www.biorxiv.org/content/10.1101/846816v2
  • Rice et al. Science (2019). 363(6423)
  • Condomitti et al. Neuron (2018). 100:201-215
  • Schroeder et al. Neuron (2018). 99:329-344
  • Schreiner et al. Curr Opin Neurobiol (2017). 42:102-110

Profile

We are seeking a highly motivated, enthusiastic, critical and creative individual to join our team. The candidate should have a strong interest in neurobiology.

Essential

  • PhD in neurobiology (molecular, cellular, developmental, systems) or related disciplines
  • A solid publication record with first-author research publication(s) in peer-reviewed international journals
  • Team player

Desirable but not required

  • Prior experience with mouse neurobiology and molecular biology
  • Prior experience with proteomics or bioinformatics

We offer

  • A versatile and challenging job in a vibrant, world-class research environment operating at an international level
  • State of the art research facilities
  • A dedicated training program to broaden your expertise and enhance your skill set
  • A competitive compensation package based on expertise and experience
  • Financial support for at least 2 years. The successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or national funding organizations)

Starting Date: as soon as possible


How to apply?


For more information contact  joris.dewit@kuleuven.vib.be. Please complete the online application procedure and include a motivation letter, a detailed CV incl. list of publications, and the contact information of three referees.


Please apply via recruiter’s website.

Quote Reference: 26796