An immediate postdoctoral position supported by NIH R01 grants is available. The main focus of the laboratory is to investigate the novel interface of stem cells with the immune system, and test whether the stem cell niche acts as an immunological sanctuary for stem cells, termed an immune privileged site, that shields normal, transplanted, and malignant stem cells from stress or immune attack.
We have recently demonstrated that the hematopoietic stem cell (HSC) niche within the bone marrow accommodates a unique regulatory T cell population that renders the niche immune privileged, further acting as novel regulators of HSC quiescence, abundance, stress, and engraftment (Cell Stem Cell 22, 445-453, 2018; Nature 474(7350), 216-9, 2011). Current research focuses include (but are not limited to) basic and translational research on this immune privilege and stem cell regulation. Multiple experimental approaches, including transgenic animal models, sequencing, and intravital two-photon microscopy, will be used. Successful candidates will have a Ph.D. and/or M.D. degree, and a strong background in stem cell biology or immunology. To apply for this position, please send your CV with names/contact info of 3 references to Dr. Joji Fujisaki (firstname.lastname@example.org).
Dr. Fujisaki’s laboratory is affiliated with Columbia Stem Cell Initiative (https://www.columbiastemcell.org) and Herbert Irving Comprehensive Cancer Center (http://cancer.columbia.edu). The laboratory is located within Columbia Center for Translational Immunology (http://www.cumc.columbia.edu/ccti/) which is a multi-departmental, multidisciplinary research center aimed at optimizing translation of advances in basic immunology from the laboratory to the clinic, understanding immunological diseases and events in humans and optimizing transfer of information and methodologies to achieve synergy between different disciplines of applied immunology.