University of Copenhagen (UCPH)

Postdoc position in pancreatic cancer bioinformatics: Interplay between environmental and genetic drivers of pancreatic ductal adenocarcinoma

Department of Biology, University of Copenhagen

Copenhagen N, Denmark

The Sandelin group is looking to recruit a talented postdoctoral researcher to our highly dynamic research group working in the interface of computational biology and genomics.

The position is for two years, available tentatively from 15 March 2020 in an interdisciplinary project entitled “Characterization of the interplay between environmental and genetic drivers of pancreatic ductal adenocarcinoma”. Pancreatic ductal adenocarcinoma (PDAC) has an exceedingly poor prognosis and is predicted to become the leading cause of cancer mortality by 2030. Characteristic hallmarks of the disease are several specific driver mutations and a dense, acidic microenvironment, yet the interplay between these factors in driving disease onset and progression is uncharacterized. In this project, an interdisciplinary team will address this question using state-of-the-art organotypic PDAC models, genomics and advanced bioinformatics approaches. The long-term goal is to identify early PDAC biomarkers and novel treatment options.

Research environment
The project is a collaboration between Prof. Albin Sandelin, BRIC and Dept. of Biology, and Prof. Stine F. Pedersen, Dept. of Biology. The candidate will be based in Albin Sandelin’s group, and will work closely with a postdoc counterpart in the Stine F Pedersen lab and several PhD students in both labs. The two groups are located within 5 minutes walking distance in the Northern Campus of the University of Copenhagen. Together, the groups employ several postdocs, PhD students, and undergraduate students and provide a strong, international research environment. The project will additionally be affiliated with the Marie Curie ITN project “pHIoniC”, in which two PhD students are already recruited for the project (one in each group).

Project and specific qualifications
The candidate will be responsible for the computational analysis of RNA-seq and DNA-sequencing data derive from organotypic PDAC models, and integrating these data with phenotypic measurements at defined time points. Work with additional data is also likely, including single cell RNA-seq and possibly CAGE data. This will be done in close collaboration with one computational PhD student and the experimental group.

Applicants must hold a PhD or equivalent in bioinformatics or a mathematical discipline with a strong biological interest, and a substantial publication record in high-quality international journals focused on the analysis of genomics data. Candidates finishing their PhD before 15 March 2019 will also be considered. We require:

• Strong experience in analyzing high-throughput sequencing data, in particular RNA-seq and variant calling
• Documented experience in statistical analyses of such data, including expression analysis, as well as quality control and visualization
• Experience in statistical genetics and statistical modelling is a large advantage
• Strong programming skills in Python and R, or equivalents, and experience using linux/unix platforms
• Excellent English skills
• One or more first authorships in well-respected bioinformatics or genomics journals
• A passion for working in a highly interdisciplinary environment.

Experience in multivariate statistics, network and time course analysis and sequence analysis are strong advantages. Similarly, experience/knowledge in cancer and cell biology is an advantage. Although the focus will be on computational work, the candidate will be working closely together with experimental scientists, and will be expected to understand the experiments and underlying biology and fruitfully interact with other specialists.

Job description
The position is available for a 2-year period and your key tasks as a postdoc at SCIENCE are:
• To manage and carry through your research project
• Write scientific articles

Further information on the Department is linked at https://www1.bio.ku.dk/english/. Inquiries about the position can be made to Prof. Albin Sandelin (albin@binf.ku.dk) or Prof. Stine F. Pedersen (sfpedersen@bio.ku.dk).

The position is open from 15 March 2020, or as soon as possible thereafter.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 434.179 including annual supplement (+ pension up to DKK 74.244). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically.

Please include, as one single file:
• Letter of introduction, explaining your interest and suitability for the position
• Curriculum vita
• Diplomas (Master and PhD degree or equivalent)
• Complete publication list
• Separate reprints of 3 particularly relevant papers
• 2-3 letters of recommendation

The deadline for applications is 5 January 2020 23:59 GMT +1.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Please apply via recruiter’s website.

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