Swiss Federal Institute of Technology in Lausanne (EPFL)

Postdoc position in dynamic chromatin signaling

Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland

Lausanne, Vaud, Switzerland

Our laboratory of Biophysical Chemistry of Macromolecules (LCBM) at the EPFL in Lausanne, Switzerland (http://lcbm.epfl.ch/) offers a fully funded postdoc positions in the field of in Biophysical Chemistry of Chromatin for the ERC funded project “Chromo-SUMMIT: Decoding dynamic chromatin signaling by single-molecule multiplex detection”


Human DNA is exposed to constant damage from external sources (UV light, reactive oxygen species etc.) or internal insults (e.g. replication fork collapse). Rapid, efficient and high-fidelity repair of DNA damage is of crucial importance for human health. DNA damage repair processes are highly complex and involve highly controlled signaling networks between protein factors and combinations of chemical modifications of chromatin.


To reveal the underlying molecular mechanisms, methods outside classical biochemistry are required. Our laboratory has pioneered many novel approaches combining chemical synthesis of defined chromatin fibers and single-molecule imaging methods to observe biology in real time.

The aim of this project is thus to develop a novel approach, combining designer chromatin synthesis and dynamic multiplex single-molecule imaging in vitro and in cells, to dissect multivalent signaling processes in chromatin – with a focus on the DNA damage response.


The ideal candidates for this position have an interest in chemical biology, biophysical chemistry or a related field and have a strong interest in elucidating molecular mechanisms in chromatin regulation. We are particular looking for candidates with a strong interest and/or background in:


- single-molecule methods in biological systems                                                              

- chemical biology of proteins and peptide chemistry

- protein purification handling and characterization

- quantitative / systems biology and modeling.


To apply for these positions, please send a letter of motivation, a CV and the contact information of 2-3 referees to Prof. Beat Fierz, beat.fierz@epfl.ch. The applications will be evaluated as they are received.

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Position

Postdoc position in dynamic chromatin signaling