IT University of Copenhagen (ITU)

Postdoc position in Development and Cancer, Faculty of Health and Medical Sciences

IT University of Copenhagen (ITU)

Copenhagen, Denmark

One postdoctoral position in Arnes group at BRIC and DanStem, University of Copenhagen

We are looking for a highly motivated and dynamic researcher, who will join a team of molecular and cellular biologists studying how the transcriptional and epigenetic regulation of cellular states drives the progression of pancreatic ductal adenocarcinoma.

Our group and research

Our group studies the molecular mechanisms that regulate cellular differentiation in pancreas development and tissue homeostasis and understand how these mechanisms contribute to the initiation and metastasis of pancreatic cancer. We consider that cancer is a disease of differentiation and that molecular regulators of cellular identity are indeed potent tumor suppressors. At DanStem and BRIC, we bring together developmental and cancer biology using a combination of in vitro differentiation of pluripotent stem cells and genetically modified mouse models of pancreatic cancer. We analyze large genomic datasets to identify signaling pathways and regulatory elements altered in cancer, and their implication in the progression of the human disease. Our work is highly interdisciplinary, from high-throughput analyses to functional studies of disease-relevant genes and regulatory elements in vitro and in vivo. We cooperate with Hospitals for a more efficient transition from basic to translational studies.

Your job

You will investigate the transcriptional and epigenetic changes that take place in the dynamic transition of cellular states in pancreatic cancer. You will investigate how regulatory elements in the genome contribute the organization of nuclear domains and the regulation of gene expression. You will use state-of-the-art technologies, such as (but not only) single-cell RNA sequencing, identification of RNA-protein interactions, chromatin conformation capture experiments and follow-up functional genomics in human cell cultures and mouse models. The ultimate goal of the project is to obtain mechanistic insights into how the dynamic transition of cellular states is regulated. You will validate the results in well-annotated clinical samples.

Profile

We expect you to be highly motivated and ambitious scientist with the following competences and experience:

Essential:

  • You hold a Ph.D. Degree in Life or Natural Sciences, preferably in Developmental Biology or Cancer
  • You are highly experienced in molecular and cellular biology and have an interest in large scale data analysis from high-throughput methods and motivation to learn new data analysis tools.
  • You are particularly interested in how developmental pathways contribute to cancer and finding new targets for translational research
  • You have an excellent track record with several published papers where your contribution was essential
  • You are highly committed to scientific research and motivated to conduct demanding research projects
  • You have proficient communication skills and ability to work in teams
  • You have excellent English skills written and spoken

Principal supervisor is Associate Professor Luis Arnes (luis.arnes@bric.ku.dk)

Start: As soon as possible, exact date after agreement. For further information regarding the position please contact Luis Arnes (luis.arnes@bric.ku.dk)

Duration: Two years with possibility of extension

Place of employment

The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD and our own Postdoc Career Programme. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu. Please read more about BRIC on http://www.bric.ku.dk/

Terms of salary and employment

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 34,079 DKK/ca. 4,570 Euro plus pension. Depending on qualifications, a higher salary may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Application procedure

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications.

Letters of recommendation

Furthermore, the shortlisted applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format and send to luis.arnes@bric.ku.dk with subject “name candidate-postdoc-year”; preferably by the supporting person. The letters should be received 1 week after being notified about shortlisting. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: 24 October 2019, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Please apply via recruiter’s website.

Quote Reference: 150207

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