KU Leuven

Postdoc position co-operative oncogenic events in acute lymphoblastic leukaemia

KU Leuven

Leuven, Belgium

The laboratory for Disease Mechanisms in Cancer (KU Leuven, Belgium) is looking for a motivated postdoctoral researcher. Our team studies the biology of acute lymphoblastic leukemia (ALL), and in particular we focus on the role of mutations in ribosomal proteins and their association with other mutations in ALL. Accumulation of mutations in ALL does not occur randomly, and particular lesions show significant co-occurrence or mutually exclusivity in the leukemia cells. This project aims at studying the molecular biological mechanisms by which co-occurring oncogenic events in T-cell ALL cooperate with each other to drive leukemia development, and how this can result in new vulnerabilities of the leukemia cells to drug treatment.

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Responsibilities

Our team identified mutations in ribosomal proteins in cancer (www.LDMC.be). The candidate will be responsible for executing the work related to the establishment of mouse models for ribosome defective ALL and using these models to explore co-operation between ribosome defects and co-occurring oncogenic events.

This work is part of a larger collaborative project involving Prof. Kim De Keersmaecker (KU Leuven), Prof.Jan Cools (KU Leuven – VIB), Prof. Johan Maertens (UZ Leuven – KU Leuven), Prof. Heidi Segers (UZ Leuven – KU Leuven) and Prof. Nancy Boeckx (UZ Leuven –KU Leuven), in which additional oncogenes in ALL are studied. The successful applicant will be responsible for coordination of this larger project and for supervising students working on different aspects of the project.

Profile

  • You obtained a PhD within the last 5 years or are close to obtaining a PhD in a relevant discipline.
  • You have a strong publication record.
  • You have a background in cancer biology and/or molecular biology.
  • Experience in working with mouse models and mammalian cell cultures as well as with standard molecular biology techniques is a strict requirement (transfection, transduction, PCR, western blotting, immunoprecipitation, cloning,…). Having a valid FELASA B certificate is a plus.
  • Experience with multicolor flow cytometry, in applying CRISPR-Cas9 technology and in performingand analyzing large –omics experiments is a plus (e.g. Chip-seq,metabolomics,…).
  • Apart from being a true team player, the candidate is expected to exhibit a high degree of independence, to have a problem-solving attitude and have strong analytical and technical abilities in addition to excellent communication and presentation skills.
  • You are fluent in English, both written and spoken.

Offer

  • An exciting job in a friendly and dynamic lab
  • A stimulating and supportive international research environment at KU Leuven, an international top research institute.
  • Excellent training opportunities to broaden your technical and academic career skills.
  • 1-year postdoctoral position with possibility of extension for at least 2 more years provided a positive evaluation. The successful candidate will also be encouraged and will get full support to obtain independent fellowships (Marie-Curie, EMBO, or National funding organizations).
  • Our lab is situated in Leuven, a charming and vibrant university city that is only a 20 minutes train ride away from the city of Brussels, at the heart of Europe.

Interested?

You can apply for this job no later than December 31, 2019 via the online application tool

Starting date: To be negotiated. Any date after January 1st 2020.

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Please apply via recruiter’s website.

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