Postdoc in Structural Biology – The Barandun lab
Our recently established research group seeks young investigators interested in joining our team as postdoctoral researcher. The Barandun lab uses innovative biochemical approaches combined with state-of-the-art tools in structural biology to study infection related processes in pathogenic organisms.
Our lab is using a combination of in-vivo assays, biochemistry and cryo-electron microscopy to study macromolecular complexes of specialized pathogenic organisms (prokaryotes and eukaryotes). We aim to provide a molecular basis of key mechanisms in infection processes and uncover unique structural determinants that could serve as novel targets for antibiotics.
Motivated candidates who would like to work in a young and dynamic team are encouraged to apply. A background in molecular biology and biochemistry is required and experience with genome manipulation techniques (e.g. CRISPR/Cas9) or structural biology a plus.
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Postdoc in Molecular Parasitology – Ellen Bushell Lab
The Bushell lab investigates the role of exported proteins in host-parasite interactions during malaria infections. We work primarily with the rodent malaria parasite Plasmodium berghei, which uniquely allows us to study these interactions in vivo. We are now looking for a postdoctoral researcher to join our growing team.
The lab uses high-throughput genetic screens, where we employ next generation sequencing to determine growth rates for individual mutants from complex pools of barcoded P. berghei mutants growing in the bloodstream of infected mice. This method can also be employed to quantify mutants in infected organs. This project will use barcode sequencing to explore the function of exported proteins in cytoadherance and sequestration.
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Postdoctoral Positions in Microbiology, Chemometrics and Analytical Chemistry – Cavalab
Our goal is to improve the inventory of players in cell wall biogenesis, remodelling and regulation, characterize the function and interplay of known components, and evolve our work into quantitative studies and computational modelling. Gathered data will have an extraordinary potential as novel targets for the development of antimicrobials.
We are currently recruiting three postdocs in microbiology, chemometrics and analytical chemistry.
• The recruited postdoc will focus on investigating bacterial cell wall dynamics and discovering novel cell wall regulatory partners. The candidate will perform state of the art UPLC-MS assays coupled with chemometric tools, live microscopy and transposon-sequencing screening among other biochemical, cell and molecular biology techniques
• The recruited postdoc will focus on the development of dedicated software for the comparative analysis of cell wall chromatographic and MS data, and generation and management of a cell wall database.
• Analytical chemistry. The recruited post-doc will be involved in the large scale, high-throughput analysis of bacterial cell wall samples using LC-MS. The person will also be responsible for the optimization and development of new analytical methods, sample preparation and analysis, and day-to-day maintenance and troubleshooting of the instruments.
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Postdoc in T cell systems biology – Henriksson lab
The recently established laboratory of Johan Henriksson is looking for a postdoctoral candidate.
You will develop the models, based on our data and data from others. You will suggest experiments and experimental design, to obtain the data the model requires. You should have a feel for designing models and/or know how to solve them. We will in particular work with sequence analysis, transcriptomics, ATAC, proteomics, metabolomics, single-cell and CRISPR. Basic knowledge of Bayesian statistics is very welcome. STAN may be useful. TensorFlow is likely to be used, and Python is likely the language of choice (but any programming language experience is already great).
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Postdoc projects in malaria parasite reproduction and transmission – Billker lab
1. Systematic identification of fertility genes in malaria parasites. Using our unique ability to carry out forward genetics screens (Bushell et al., Cell, 2017), you will develop assays to identify experimentally all parasite genes involved in specific aspects of male or female fertility, which is essential for parasite transmission to the vector.
2. Single Cell Biology of Malaria Transmission. Using single cell transcriptomics (scRNAseq, e.g. Reid et al., eLife, 2018), you will carry out an in-depth analysis of developmental mutants, using their unique transcriptional signatures to propose genetic networks and mechanisms of parasite development during transmission. You may visit collaborators in endemic countries for a comparative analysis of rodent and other animal models with parasites infecting humans.
3. Mechanisms of Plasmodium sex determination and sexual stage differentiation. Outgoing from a list of candidate nucleic acid binding proteins which have already emerged from a genetic screen, you will use ChIP, single cells RNAseq and protein interaction studies to elucidate the molecular mechanisms of development in a divergent eukaryote downstream of the master regulator, transcription factor ap2-g (Sinha et al., Nature, 2014).
4. Evolution of sexual processes in a divergent eukaryote. You will exploit the position of malaria parasites in the tree of life to reveal the most conserved molecules in cellular processes involved in eukaryotic sexual reproduction (e.g. the axoneme, meiosis, gamete fusion), as well as discover some of the unique biology of apicomplexan parasites.
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The Laboratory for Molecular Infection Medicine Sweden (MIMS, www.mims.umu.se) is the only Swedish laboratory within the Nordic EMBL Partnership for Molecular Medicine (www.nordicemblpartnership.org), a joint collaboration between the European Molecular Biology Laboratory (EMBL, www.embl.de) and the Institute for Molecular Medicine Finland (FIMM), the Centre for Molecular Medicine Norway (NCMM), the Danish Research Institute of Translational Neuroscience (DANDRITE). The partnership is dedicated to the growing field of life sciences that investigates the molecular basis of disease and explores molecularly and genetically based treatments.
MIMS is funded by the Swedish Research Council (VR) and Umeå University and established as Swedish Molecular Medicine Laboratory in accordance with the core principles of the European Molecular Biology Laboratory (EMBL). MIMS aims to develop the careers of the next generation of researchers in infectious diseases and to link Swedish infection researchers to other European centres of excellence in molecular medicine.
MIMS was founded and established by researchers within the Umeå Centre for Microbial Research (UCMR, www.ucmr.umu.se), a VR-funded Centre of Excellence that now includes more than 50 research groups in molecular and clinical microbiology, molecular biology, chemistry and physics.
To promote translational research and to build a network of clinicians, a program of MIMS Clinical Research Fellowships has so far supported eleven medical doctors working in all university hospitals in Sweden. Supported by the Swedish Research Council (VR), MIMS also coordinates the National Doctoral Programme in Infections and Antibiotics (NDPIA,www.ndpia.se).
About Umeå University:
Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programmes, world leading research, and excellent innovation and collaboration opportunities. More than 4 000 employees and 30 000 students have already chosen Umeå University. We welcome your application!
About the Department of Molecular Biology:
The Department of Molecular Biology is unique, being affiliated to both the Faculty of Science and Technology and to the Faculty of Medicine. The department has a pronounced dynamic international profile with faculty, students and guest researchers from more than 30 different countries. Researchers work in modern laboratories with well-equipped common facilities to create a framework for a creative and highly interactive environment. Specific research interests of the independent groups are interconnected by a common interest in fundamental and translational research concerning the molecular mechanisms of both bacterial and eukaryotic systems.
Many of our research groups are affiliated with the interdisciplinary “Umeå Centre for Microbial Research” (UCMR) founded by our department. The department also hosts "Molecular Infection Medicine Sweden (MIMS) – the Swedish node of “The Nordic-EMBL Partnership for Molecular Medicine”. As the main driver of these centres of excellence and one of the largest departments at Umeå University, we provide undergraduate courses within Medical, Dental, Life Science, and Civil Engineer programs. For further information, please pursue the links below.
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