B lymphocytes play important roles as drivers and regulators of immune-mediated inflammatory diseases through the production of cytokines. We previously showed that B cells could regulate immunity through the provision of IL-10 and IL-35 (Nature Immunology 2002, Immunity 2010, Nature 2014, Immunity 2018). We have also established that B cells promoted the pathogenesis of autoimmune disease through the production of IL-6 (J Exp Med 2012). This post-doctoral position will be dedicated to the investigation of the molecular mechanisms controlling the production of pro-inflammatory cytokines by B cells, with a particular focus on IL-6, with the aim to find molecular signatures for IL-6-producing B cells, and modalities to interfere with their differentiation as well as pathogenic functions.
The project will use IL-6 reporter mice recently developed in our group, as well as state-of-the-art biochemical, proteomics, and genetics tools to explore the function of key regulators we have recently identified. The project will involve work in mouse and human cells.
The Institut Necker-Enfants Malades (INEM) with its two departments in immunology and cellular biology, its intimate partnerships with the IMAGINE institute, the Necker Enfants-Malades Hospital, and the performant core facilities available on site (https://www.necker.fr//sfr-necker/index.php?menu=platforms&lang=uk) offers an excellent environment to conduct these studies. The laboratory “Immunity in Health and Disease” thus provides a unique opportunity to work at the interface between fundamental and clinical research.
The project is funded by a European Research Council (ERC) grant. An expertise in biochemistry, molecular biology, and cellular immunology is welcome.
The position is open. Salary will be according to experience following INSERM regulation.
Please send your application via email in English with CV, a brief outline of previous research, and contact details of three references to: email@example.com ; firstname.lastname@example.org
INEM - INSERM U 1151
156-160 rue de Vaugirard
Selected publications from the team:
Lino AC. et al. Immunity. 2018. vol. 49 p120-133.
Kieback et al. Immunity. 2016. vol. 44 p1114-1126.
Shen et al. Nature Reviews Immunology. 2015. vol. 15 p441-451.
Shen P. et al. Nature. 2014. vol. 507 p366-370.
Neves P. et al. Immunity. 2010. vol. 33 p777-790.
Fillatreau S. et al. Nature Reviews Immunology. 2008. vol. 8 p391-397.
Fillatreau S. et al. Nature Immunology. 2002. vol