Context of intervention
Proteomics for precision or personalised medicine applications requires the development of an effective screening instrument capable of detecting proteins at low concentrations. The ElectroMed project’s objective is to build and validate a proof-of-concept prototype of a programmable high-throughput peptide microarray. It is based on integrating electrochemical synthesis of peptide bio-receptors with nano-functionalised Field Effect Transistor (FET) sensors for high-performance data acquisition within a microfluidic-driven multiplexed platform for parallel screening.
The ElectroMed project is carried out by several European partners each with their own responsibility and work package. One of the tasks is the development of a bio-interface for a label-free FET sensor, which is one of the key deliverables of the project.
It is your job to fabricate and characterize the interface using surface characterisation methods like quartz crystal microbalance and SPR. In addition, you will implement the interface in FETs and characterise the performance of the sensors.
- PhD in electrochemistry, organic chemistry, or equivalents
- PhD is necessary, experience on microfluidics will be appreciated
- Surface functionalisation of inorganic substrate such as silicon, glass and gold
- Hands on experience working with bio-assays, and bio-assay optimisation
- Experience with the use of real time analysis tools (i.g. XPR, QCM) to monitor and quantify bimolecular interactions
- Experience investigating protein-peptide interactions, microfabrication in a clean room setting will be considered a plus
- Fluency in spoken and written English communication skills is necessary
- French language skills would be a plus