KTH Royal Institute of Technology

Postdoc in Systems and Synthetic Biology of Host-Microbiome Interaction

KTH Royal Institute of Technology

Stockholm, Sweden

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

Job description

The progression of conditions such as chronic kidney disease (CKD), liver cirrhosis (LC) and Crohn’s diseases (CD), could be the mediation of interplays between different host tissues, and microbiome. Changes in diet, medication (such as antibiotics), and microbiome could impact the host physiology towards more progression in chronic conditions and also changes in the gut that impair barrier function and release of microbial metabolites, live microorganism and residue into the circulation. Thus, investigating the whole-body multi-omics in the chronic conditions and targeted therapies are the way forward.

Here, we take a holistic approach to understand the role of different tissues and microbiome, together with diet to elucidate the interactions between them. We investigate the relationship between fibrosis process, inflammation, metabolism and microbiome using multi-omics data in CD, CKD & LC. We are now seeking one postdoc with strong skills to first work on performing multi-omics analysis to understand the diseases progression. Second, we aim to develop CRISPR-based method to modify the microbiome targeted to attack specific pathogens as potential future therapy instead of antibiotic administration and overcome resistance. In addition, the post could contribute to the expansion of our recently developed human microbiome atlas.

What we offer

• An international workplace.
• A leading technical university that creates knowledge and expertise for a sustainable future.
• Here you have colleagues with high ambitions in an open, curious and dynamic environment.
• Help to relocate and be settled in Sweden and at KTH.
• We are developing a new lab within the division of Systems Biology presently consisting of three research groups focusing on systems biology related research.
https://www.kth.se/pro/sysbio
https://www.sysbiomelab.com

Qualifications

Requirements
The candidate is expected to perform research in Molecular, Computational and Synthetic Biology in host and microbiome area with a relevant PhD subject. Degree must have been completed no more than three years before the application deadline.

We are looking for a scientist with the following qualifications:

-Proven record within molecular and systems biology, experience with multi-omics data analysis and integration.

- Experience with CRISPR technology, developing vectors for simultaneous targeted insertion in multiple genomic sites.

*Preferred qualifications *

We prefer the candidate have a strong background in systems biology, molecular biology methods, CRISPR technology, omics analysis and statistics. The candidate should be highly motivated for doing scientific research related to human diseases and should have well developed analytical and problem-solving skills. Additionally, the candidates should have excellent written, oral communication skills.
You possess scientific skill and good pedagogical ability. You have good collaboration and can work independently. You are well aware of diversity and equal treatment issues with a special focus on gender equality.

Great emphasis will be placed on personal competence and suitability.
Trade union representatives

You will find contact information to trade union representatives at KTH.se

Application

Log into KTH’s recruitment system in order to apply to this position. You are responsible to ensure that your application is complete according to the instructions in the ad.

Instruction:
The application must include:

• CV including relevant professional experience and knowledge.
• Copy of diplomas and grades or confirmation letter from your previous university studies. Translations into English or Swedish if the original documents have not been issued in any of these languages.
• Brief account of why you want to conduct research, your academic interests and how they relate to your previous studies and future goals. Max two pages long.

Your complete application must be received by KTH no later than the last day of application, midnight
CET/CEST (Central European Time/Central European Summer Time).

Temporary employment for up to 24 months.

About the employment

The position offered is for, at the most, two years
A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.

Other information

Gender equality, diversity and zero tolerance against discrimination and harassment are important aspects of KTH’s work with quality as well as core values in our organization.

For information about processing of personal data in the recruitment process please read here.

We firmly decline all contact with staffing and recruitment agencies and job ad salespersons.

Please apply via recruiter’s website.

Quote Reference: C-2020-0997